Tuesday, July 18, 2006

The SENS debate, continued

As I promised to try to do, I read Estep et. al's submission to TR's challenge, the one the judging panel declared to be the "most eloquent", along with de Grey's response and the author's rebuttal. Estep et. al. misunderstand their role in the challenge from beginning to end. de Grey has been promoting SENS, a proposal for a new approach to combat aging, for a few years. From the beginning he admitted it was a controversial approach combining leading edge biology and an engineering mindset and asked experienced scientists to tell him if he was making any fundamental mistakes in the science. He has led and participated in symposia with experts and published papers in respected journals, after earning a Ph.D. in the relevant discipline. Technology Review solicited written submissions that would demonstrate that de Grey's program was "so wrong that it was unworthy of learned debate."

There are good reasons for practicing scientists to recognize the signs of pseudo-science, and it's appropriate for their first reaction to be outright dismissal when they recognize those signs. When a proposal garners enough attention that outright dismissal is no longer effective, it's still appropriate for most scientists to ignore it until there's more evidence in its favor. But at the point at which someone decides that a head-on confrontation is called for, the participants in the process should no longer expect to get away with derision; their role at that point is to review the science, show that the conclusions are at odds with established results, or demonstrate that they can't be disproved in principal, and thus are outside the bounds of science. Their goal should be to analyze the proposals, and summarize their evaluation in enough detail that other scientist can read their summary rather than doing the primary analysis themselves.

Estep et. al. spend an inordinate amount of time referring to studies of pseudo-science and its practitioners, and explaining in what ways de Grey and his proposal resembles them. But that's of no value at this stage in the process. Pontin (the editor of TR, and instigator of the challenge) and de Grey's other detractors have already pointed out that SENS isn't normal science; the challenge is to come up with an evaluation of the science, and Estep skimps on that.

Estep accuses de Grey of tangling his new proposals in with other scientists' results, making it hard to distinguish what is well-founded from what is not. But that's part of the normal process of science. Scientists build on others' work, expand it in some areas, and correct mistakes in others. In effect, Estep's charge is that scientists perpetrating fraud should clearly separate their new fraudulent work from others' well-founded work in order to make the investigator's job easier. This is nonsense. It is Estep's responsibility to examine the foundations of SENS and find parts that aren't justified or justifiable. If he can't, he has failed to undercut the science. That failure wouldn't by itself show that SENS is valid, but it would be a hurdle passed. Becoming accepted as established science is a process of continuing to get past the hurdles.

Estep shows no evidence that he understands the distinction that de Grey makes in referring to SENS as an engineering approach. de Grey is very clear in drawing the distinction:

Concerning the difference between scientists and engineers in mindset and motivation — as opposed to laboratory expertise — that I have often mentioned, Estep et al. expertly make my point for me by noting that the only reason they engineer model organisms is to find things out. To quote them: "If we could easily predict the outcome, why bother going through all the trouble of actually doing the engineering?". I wonder if Estep et al. think the Wright brothers built their airplane in order to discover whether it would fly? I personally suspect that they built it because they were confident that it would fly and they wanted to build something that would fly. Estep et al.'s oversight of this motivation is quite breathtaking to anyone who understands that, since aging causes immense suffering and death, it is something to be explored not for the sake of curiosity alone but with the goal of actually doing something about it.

In their response, Estep et. al. point out that the Wright brothers used the scientific process to test and evaluate the components they were building, and that they were systematic in their efforts to evaluate all the effects that mattered in getting into and remaining in the air. This response completely misses the point. Estep et. al. think that progress is made by systematically expanding the frontier of what is known. de Grey proposes to take what is known and build an effective mechanism to solve a problem, learning as he goes. The relevant question is whether we know enough at this point to start the process. The Wright brothers didn't know the answers when they started. They weren't satisfied with asking all the interesting questions, either; they asked the questions that were blocking their path to building a successful flying machine. Useful questions for critiquing an engineering proposal include: Do we know enough to get started? Is the cost estimate reasonable? Are there reasons to believe that there is no solution to the problem (within the budget)?

Estep et. al. focus on showing that some of the particular approaches that de Grey suggests aren't completely justified in the literature. But the heart of the SENS proposal is a search for solutions to 7 identified pathologies; de Grey has identified multiple approaches to each of them, and tried to give plausible detail about at least one solution for each problem. The useful counter-arguments are that these 7 aren't exhaustive, or that no (affordable) solution is available to one or more of the seven. Estep et. al. say that de Grey's list of 7 pathologies "unscientifically exclud[es] others"; the only exclusion I can identify in their paper is "unrepaired DNA damage in post-mitotic tissues", though they also mention "largely uncharacterized and undiscovered damage and pathologies". de Grey's original claim about the seven pathologies was that these seven had all been identified and characterized by 1982, and no new ones have become apparent since then despite all the advances and attention in this area, so "uncharacterized and undiscovered" looks like a clear miss to me. de Grey's response to the post-mitotic damage is to point out that he had addressed that issue in a draft paper that Estep has been asked to review. Estep talks about other items covered in that paper, but drops the thread on post-mitotic damage. I count that as no challenge to de Grey's claim that there are only seven pathologies to worry about.

de Grey wrote in his rebuttal:

Particularly incongruous is their accusation that I use the media to skirt expert criticism, when the SENS Challenge itself is my most conspicuous effort to do just the reverse, exposing the public reticence of SENS's off-the-record detractors and thereby forcing them to make their supposed case in print.

(de Grey has made other efforts to get gerontologist to put their objections on the record.) Estep responds thusly:

TR Editor Jason Pontin claims this challenge was initiated by him and all available evidence supports this claim. Furthermore, we have evaluated only a few of SENS' weaknesses, as did Warner and colleagues (Warner et al. 2005), and Aubrey de Grey's responses demonstrate beyond a shadow of a doubt that he is completely insincere in his wish for scientists to critique SENS.

Notice that Estep wrote in the original paper:

This SENS Challenge is itself part of the pseudoscience archetype, and it is simply a culmination of ongoing challenges made by Aubrey de Grey to opponents of SENS to prove him wrong. This is a classic attempt to subvert the scientific process, it is known to be typical of pseudoscience, and it is described as such in Dr. Friedlander's book, which predates SENS by several years.

So, Estep started this particular exchange by saying that the SENS Challenge is stereotypical behavior of pseudoscientists; de Grey rebuts that the challenge is an example of his having solicited criticism, at which point Estep backtracks and says that de Grey wasn't responsible for the challenge anyway. de Grey's Methuselah Foundation had matched Technology Review's prize for which Estep competed. Seems like de Grey is on solid ground in describing his role as helping to encourage debate.

Estep's rebuttal contains a number of explicit "predictions". That interests me because of the obvious application of prediction markets to monitor the argument. Most of the predictions are untestable or uninteresting: "de Grey's complaints that he isn't getting a fair hearing will continue", "Very soon it will be apparent to all [...] that SENS [...] constitutes overt scientific misconduct." Two exceptions are worth noting.

First, Estep et. al. say "[de Grey]'s only contribution to pharmacological inhibition and modification [...] of telomerase, therapeutic deletion of the entire telomerase gene [...] from the genome, will be recognized to be a crude biomedical fantasy. It will be abandoned by all sensible people--and even de Grey's co-authors will cease to [...] discuss it publicly." This is a very hard statement to write a clear prediction market claim for. We've tried before, on FX for claims that a consensus will arise, or that some research field will be dropped, but the claim details are hard to agree on and judge. I'll leave the prediction standing here as a reminder that de Grey's opponents can be judged to have made a valid prediction if, in your opinion, this subfield goes away later.

The second prediction is easier to adapt as a prediction market claim. The background is that de Grey is apparently accepted as an expert in the area of mitochondrial DNA (mDNA) mutation and repair. His proposal to combat progressive damage to mDNA is to ensure that Nuclear DNA (nDNA) can construct the few proteins (that's "allotropic expression") that the mitochondrion can't already get from the cell's nucleus. de Grey's response says

the shallowness of Estep et al.'s analysis is revealed especially starkly by their contradictory statements concerning allotropic expression in cell culture, which midway through their analysis they call an example of "assumptions and technologies that reside firmly in the realm of fantasy" but, in their summary, they call an example of "routine biology experiments."

Estep et. al. respond

successful allotropic expression of all 13 mitochondrial coding regions while maintaining mitochondrial and cellular function is a technology that resides in the realm of fantasy. Nevertheless, attempts to achieve these things are without a doubt routine biology experiments.

This makes it appear that Estep et. al. are willing to use the word "fantasy" to describe things that haven't been achieved yet. At least they didn't make any attempt to show that it couldn't be achieved.

Estep et. al. point out that de Grey bet someone publicly in 2000 that this would be known technology before the end of 2005, and it still hasn't been achieved. de Grey responds that he was counting on the imminent release of a paper showing the technique was possible (which was in review at that point) to spur further work. The paper only came out in 2005, so the follow-on work has only just started.

Estep's one explicit prediction is "We believe that this problem is [complicated] and it will remain unsolved for a very long time--if it is ever solved. Aubrey de Grey will continue to make excuses [...] to explain the lack of progress in this area." This, unfortunately, doesn't give a useful time scale, but de Grey's original projection can be extended to give a reasonable deadline.

Here is the background de Grey gives:

They lampoon my prediction from 2000 concerning AE, without mentioning that I made it assuming that Zullo et al.'s seminal breakthrough ( which I presented at the time I made the bet) would be published imminently in Science (where it was then in review), stimulating effort to perfect this approach; in fact, followup effort remained negligible until it was finally published in 2005. Thus, it is grossly misleading to suggest that my overoptimism arose from underestimating how hard AE is — and I fully explained this recently in a reply to Estep on a well-known mailing list (subscription required in order to review archives).

So in 2000, de Grey expected that imminent publication in Science would produce results by 2005. The paper was published in 2005, but not in a publication as prestigious as Science. Estep says it will be a very long time if ever. I'll propose a claim for the Foresight Exchange that it will be solved by 2012, which is longer than the 5 years de Grey originally expected, but gives some leeway for the reduced publicity the paper actually got. If it still seems to be 5 years away at that point, we'll have to conclude that de Grey's timeframes were way off.

Overall, I have to agree with TR's panel. Estep et. al. may have found some holes in de Grey's specific proposed therapies (it's hard for me to tell; unlike de Grey, Estep et. al. don't provide layman's versions of any of their technical arguments), but they didn't show that these holes make the entire effort unlikely to succeed, and they didn't show that de Grey's proposal doesn't address a useful goal.

As Marc Stiegler commented when I told him who was on the review committee, they seem predisposed to finding merit in de Grey's plan. Ventner is best known for his public commitment to develop technology to sequence the human genome before it was scientifically justifiable--and delivered. Rod Brooks' mantra at the Mobile Robot Lab was "fast, cheap, and out of control"; they were building stuff that worked rather than pursuing pure knowledge. Nathan Myhrvold is more focused on inventions than basic research, even though his academic credentials are impeccable.

added 12/15/2006

I created the mtDNA claim on FX in August.

7 comments:

mrrobbins said...

So Chris, Here's what I don't get. How is it that you think you are qualified to second guess the scientists who are actually doing the research? I'm not sure what Estep's qualifications are, but have you looked at the list of his co-authors? These people are some of the brightest stars in aging reserach. My take is that the real scientists are pretty much unanimous that SENS has absolutely no chance of working.

De Grey has been whining for a long time that he couldn't get qualified scientists to evaluate his work. Well, they have now.

mrrobbins said...

Just to make my point. Here are some of the papers published by Estep's coauthors. Who are you going to believe?

1: Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA.
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and
DAF-16/FOXO.
Mech Ageing Dev. 2006 Jul 20; [Epub ahead of print]
PMID: 16860373 [PubMed - as supplied by publisher]

2: Kaeberlein M.
Genome-wide approaches to understanding human ageing.
Hum Genomics. 2006 Jun;2(6):422-8.
PMID: 16848980 [PubMed - in process]

3: Mukhopadhyay A, Oh SW, Tissenbaum HA.
Worming pathways to and from DAF-16/FOXO.
Exp Gerontol. 2006 Jul 11; [Epub ahead of print]
PMID: 16839734 [PubMed - as supplied by publisher]

4: Olsen A, Vantipalli MC, Lithgow GJ.
Lifespan extension of Caenorhabditis elegans following repeated mild hormetic
heat treatments.
Biogerontology. 2006 Jul 7; [Epub ahead of print]
PMID: 16826446 [PubMed - as supplied by publisher]

5: Martin GM, Kennedy D.
SAGE lessons.
Science. 2006 Jul 7;313(5783):17. No abstract available.
PMID: 16825538 [PubMed - indexed for MEDLINE]

6: Nitta RT, Jameson SA, Kudlow BA, Conlan LA, Kennedy BK.
Stabilization of the retinoblastoma protein by A-type nuclear lamins is
required for INK4A-mediated cell cycle arrest.
Mol Cell Biol. 2006 Jul;26(14):5360-72.
PMID: 16809772 [PubMed - in process]

7: Maezawa I, Hong HS, Wu HC, Battina SK, Rana S, Iwamoto T, Radke GA,
Pettersson E, Martin GM, Hua DH, Jin LW.
A novel tricyclic pyrone compound ameliorates cell death associated with
intracellular amyloid-beta oligomeric complexes.
J Neurochem. 2006 Jul;98(1):57-67.
PMID: 16805796 [PubMed - in process]

8: Olsen A, Vantipalli MC, Lithgow GJ.
Using Caenorhabditis elegans as a model for aging and age-related diseases.
Ann N Y Acad Sci. 2006 May;1067:120-8. Review.
PMID: 16803977 [PubMed - indexed for MEDLINE]

9: Deplancke B, Mukhopadhyay A, Ao W, Elewa AM, Grove CA, Martinez NJ, Sequerra
R, Doucette-Stamm L, Reece-Hoyes JS, Hope IA, Tissenbaum HA, Mango SE, Walhout
AJ.
A gene-centered C. elegans protein-DNA interaction network.
Cell. 2006 Jun 16;125(6):1193-205.
PMID: 16777607 [PubMed - in process]

10: Olsen A, Vantipalli MC, Lithgow GJ.
Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis
elegans.
Science. 2006 Jun 2;312(5778):1381-5.
PMID: 16741121 [PubMed - indexed for MEDLINE]

11: Kaeberlein M, Steffen KK, Hu D, Dang N, Kerr EO, Tsuchiya M, Fields S,
Kennedy BK.
Comment on "HST2 mediates SIR2-independent life-span extension by calorie
restriction".
Science. 2006 Jun 2;312(5778):1312; author reply 1312.
PMID: 16741098 [PubMed - indexed for MEDLINE]

12: Huang S, Lee L, Hanson NB, Lenaerts C, Hoehn H, Poot M, Rubin CD, Chen DF,
Yang CC, Juch H, Dorn T, Spiegel R, Oral EA, Abid M, Battisti C, Lucci-Cordisco
E, Neri G, Steed EH, Kidd A, Isley W, Showalter D, Vittone JL, Konstantinow A,
Ring J, Meyer P, Wenger SL, von Herbay A, Wollina U, Schuelke M, Huizenga CR,
Leistritz DF, Martin GM, Mian IS, Oshima J.
The spectrum of WRN mutations in Werner syndrome patients.
Hum Mutat. 2006 Jun;27(6):558-67.
PMID: 16673358 [PubMed - indexed for MEDLINE]

13: Xu Y, Leung CG, Lee DC, Kennedy BK, Crispino JD.
MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription
and promotes erythroid cell differentiation.
Leukemia. 2006 Jul;20(7):1261-9. Epub 2006 May 4.
PMID: 16673016 [PubMed - in process]

14: Fisher AL, Lithgow GJ.
The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis
elegans lifespan and regulates genes repressed in multiple long-lived worms.
Aging Cell. 2006 Apr;5(2):127-38.
PMID: 16626392 [PubMed - indexed for MEDLINE]

15: Martin GM.
Keynote lecture: an update on the what, why and how questions of ageing.
Exp Gerontol. 2006 May;41(5):460-3. Epub 2006 Apr 18.
PMID: 16621387 [PubMed - in process]

16: Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S,
Kennedy BK.
Author's Reply.
PLoS Genet. 2006 Mar;2(3):e34. No abstract available.
PMID: 16596164 [PubMed - in process]

17: Lin YT, Hoang H, Hsieh SI, Rangel N, Foster AL, Sampayo JN, Lithgow GJ,
Srinivasan C.
Manganous ion supplementation accelerates wild type development, enhances
stress resistance, and rescues the life span of a short-lived Caenorhabditis
elegans mutant.
Free Radic Biol Med. 2006 Apr 1;40(7):1185-93. Epub 2005 Dec 12.
PMID: 16545686 [PubMed - indexed for MEDLINE]

18: Frock RL, Kudlow BA, Evans AM, Jameson SA, Hauschka SD, Kennedy BK.
Lamin A/C and emerin are critical for skeletal muscle satellite cell
differentiation.
Genes Dev. 2006 Feb 15;20(4):486-500.
PMID: 16481476 [PubMed - indexed for MEDLINE]

19: Xia XG, Zhou H, Samper E, Melov S, Xu Z.
Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes
of the gene knockout in mice.
PLoS Genet. 2006 Jan;2(1):e10. Epub 2006 Jan 27.
PMID: 16450009 [PubMed - indexed for MEDLINE]

20: Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S.
Extension of chronological life span in yeast by decreased TOR pathway
signaling.
Genes Dev. 2006 Jan 15;20(2):174-84.
PMID: 16418483 [PubMed - indexed for MEDLINE]

21: Cutler R, Guarante LP, Kensler TW, Naftolin F, Jones DP, Cantor CR, Martin
GM.
Longevity determinant genes: what is the evidence? What's the importance? Panel
discussion.
Ann N Y Acad Sci. 2005 Dec;1055:58-63. No abstract available.
PMID: 16387718 [PubMed - indexed for MEDLINE]

22: Martin GM.
Genetic engineering of mice to test the oxidative damage theory of aging.
Ann N Y Acad Sci. 2005 Dec;1055:26-34. Review.
PMID: 16387715 [PubMed - indexed for MEDLINE]

23: Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA.
Identification of direct DAF-16 targets controlling longevity, metabolism and
diapause by chromatin immunoprecipitation.
Nat Genet. 2006 Feb;38(2):251-7. Epub 2005 Dec 25.
PMID: 16380712 [PubMed - indexed for MEDLINE]

24: Loeb LA, Wallace DC, Martin GM.
The mitochondrial theory of aging and its relationship to reactive oxygen
species damage and somatic mtDNA mutations.
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18769-70. Epub 2005 Dec 19. No
abstract available.
PMID: 16365283 [PubMed - indexed for MEDLINE]

25: Yang Z, Cool BH, Martin GM, Hu Q.
A dominant role for FE65 (APBB1) in nuclear signaling.
J Biol Chem. 2006 Feb 17;281(7):4207-14. Epub 2005 Dec 6.
PMID: 16332686 [PubMed - indexed for MEDLINE]

26: Morten KJ, Ackrell BA, Melov S.
Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2:
attenuation via antioxidant treatment.
J Biol Chem. 2006 Feb 10;281(6):3354-9. Epub 2005 Dec 2.
PMID: 16326710 [PubMed - indexed for MEDLINE]

27: Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S,
Kennedy BK.
Increased life span due to calorie restriction in respiratory-deficient yeast.
PLoS Genet. 2005 Nov;1(5):e69. Epub 2005 Nov 25.
PMID: 16311627 [PubMed - in process]

28: Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO,
Kirkland KT, Fields S, Kennedy BK.
Regulation of yeast replicative life span by TOR and Sch9 in response to
nutrients.
Science. 2005 Nov 18;310(5751):1193-6.
PMID: 16293764 [PubMed - indexed for MEDLINE]

29: Kennedy BK, Smith ED, Kaeberlein M.
The enigmatic role of Sir2 in aging.
Cell. 2005 Nov 18;123(4):548-50.
PMID: 16286003 [PubMed - indexed for MEDLINE]

30: Wang Y, Tissenbaum HA.
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and
DAF-16/FOXO.
Mech Ageing Dev. 2006 Jan;127(1):48-56. Epub 2005 Nov 8.
PMID: 16280150 [PubMed - indexed for MEDLINE]

31: Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes
BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T,
Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L,
Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei
JY, Williams TF.
Science fact and the SENS agenda. What can we reasonably expect from ageing
research?
EMBO Rep. 2005 Nov;6(11):1006-8. No abstract available.
PMID: 16264422 [PubMed - in process]

32: Kuzdzal S, Lopez M, Mikulskis A, Golenko E, DiCesare J, Denoyer E, Patton
W, Ediger R, Sapp L, Ziegert T, Ackloo S, Wall MR, Mannion DP, della Cioppa G,
Wolfe G, Bennett D, Melov S.
Biomarker discovery and analysis platform: application to Alzheimer's disease.
Biotechniques. 2005 Oct;39(4):606-7. No abstract available.
PMID: 16235574 [PubMed - indexed for MEDLINE]

33: Huang S, Chen L, Libina N, Janes J, Martin GM, Campisi J, Oshima J.
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA
interference.
Hum Genet. 2005 Dec;118(3-4):444-50. Epub 2005 Oct 6.
PMID: 16208517 [PubMed - indexed for MEDLINE]

34: Stringer KG, Martin GM, Skinner DM.
The effects of hippocampal lesions on response, direction, and place learning
in rats.
Behav Neurosci. 2005 Aug;119(4):946-52.
PMID: 16187822 [PubMed - indexed for MEDLINE]

35: Kudlow BA, Jameson SA, Kennedy BK.
HIV protease inhibitors block adipocyte differentiation independently of lamin
A/C.
AIDS. 2005 Oct 14;19(15):1565-73.
PMID: 16184025 [PubMed - indexed for MEDLINE]

36: Grabowski MM, Svrzikapa N, Tissenbaum HA.
Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans.
Mech Ageing Dev. 2005 Dec;126(12):1314-21. Epub 2005 Sep 21.
PMID: 16181657 [PubMed - indexed for MEDLINE]

37: Wolf N, Penn P, Pendergrass W, Van Remmen H, Bartke A, Rabinovitch P,
Martin GM.
Age-related cataract progression in five mouse models for anti-oxidant
protection or hormonal influence.
Exp Eye Res. 2005 Sep;81(3):276-85.
PMID: 16129095 [PubMed - indexed for MEDLINE]

38: Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA,
Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI.
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
J Clin Invest. 2005 Sep;115(9):2556-63. Epub 2005 Aug 25.
PMID: 16127459 [PubMed - indexed for MEDLINE]

39: Beckman KB, Lee KY, Golden T, Melov S.
Gene expression profiling in mitochondrial disease: assessment of microarray
accuracy by high-throughput Q-PCR.
Mitochondrion. 2004 Sep;4(5-6):453-70. Epub 2004 Sep 30.
PMID: 16120406 [PubMed]

40: McColl G, Vantipalli MC, Lithgow GJ.
The C. elegans ortholog of mammalian Ku70, interacts with insulin-like
signaling to modulate stress resistance and life span.
FASEB J. 2005 Oct;19(12):1716-8. Epub 2005 Aug 12.
PMID: 16099946 [PubMed - indexed for MEDLINE]

41: Parmar H, Melov S, Samper E, Ljung BM, Cunha GR, Benz CC.
Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary
glands oxidatively stressed by loss of mitochondrial superoxide dismutase.
Breast. 2005 Aug;14(4):256-63. Epub 2005 Apr 19.
PMID: 16085231 [PubMed - indexed for MEDLINE]

42: Mukhopadhyay A, Deplancke B, Walhout AJ, Tissenbaum HA.
C. elegans tubby regulates life span and fat storage by two independent
mechanisms.
Cell Metab. 2005 Jul;2(1):35-42.
PMID: 16054097 [PubMed - indexed for MEDLINE]

43: Martin GM.
Epigenetic drift in aging identical twins.
Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10413-4. Epub 2005 Jul 18. No
abstract available.
PMID: 16027353 [PubMed - indexed for MEDLINE]

44: Mahoney DJ, Parise G, Melov S, Safdar A, Tarnopolsky MA.
Analysis of global mRNA expression in human skeletal muscle during recovery
from endurance exercise.
FASEB J. 2005 Sep;19(11):1498-500. Epub 2005 Jun 28.
PMID: 15985525 [PubMed - indexed for MEDLINE]

45: Golden TR, Hubbard A, Morten KJ, Hinerfeld D, Melov S.
Pharmacogenomic profiling of an oxidative stress-mediated spongiform
encephalopathy.
Free Radic Biol Med. 2005 Jul 15;39(2):152-63. Epub 2005 Mar 30.
PMID: 15964507 [PubMed - indexed for MEDLINE]

46: Barbie DA, Conlan LA, Kennedy BK.
Nuclear tumor suppressors in space and time.
Trends Cell Biol. 2005 Jul;15(7):378-85. Review.
PMID: 15936946 [PubMed - indexed for MEDLINE]

47: Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun
PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS.
Extension of murine life span by overexpression of catalase targeted to
mitochondria.
Science. 2005 Jun 24;308(5730):1909-11. Epub 2005 May 5.
PMID: 15879174 [PubMed - indexed for MEDLINE]

48: Huang S, Kennedy BK, Oshima J.
LMNA mutations in progeroid syndromes.
Novartis Found Symp. 2005;264:197-202; discussion 202-7, 227-30. Review.
PMID: 15773755 [PubMed - indexed for MEDLINE]

49: Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA.
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear
translocation of forkhead transcription factor/DAF-16.
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4494-9. Epub 2005 Mar 14.
PMID: 15767565 [PubMed - indexed for MEDLINE]

50: Martin GM.
Genetic modulation of senescent phenotypes in Homo sapiens.
Cell. 2005 Feb 25;120(4):523-32. Review.
PMID: 15734684 [PubMed - indexed for MEDLINE]

51: Kaeberlein M, Kirkland KT, Fields S, Kennedy BK.
Genes determining yeast replicative life span in a long-lived genetic
background.
Mech Ageing Dev. 2005 Apr;126(4):491-504. Epub 2005 Jan 7.
PMID: 15722108 [PubMed - indexed for MEDLINE]

52: Smith ED, Kudlow BA, Frock RL, Kennedy BK.
A-type nuclear lamins, progerias and other degenerative disorders.
Mech Ageing Dev. 2005 Apr;126(4):447-60. Epub 2004 Dec 15. Review.
PMID: 15722103 [PubMed - indexed for MEDLINE]

53: Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD,
Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.
Substrate-specific activation of sirtuins by resveratrol.
J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.
PMID: 15684413 [PubMed - indexed for MEDLINE]

54: Hu Q, Wang L, Yang Z, Cool BH, Zitnik G, Martin GM.
Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent
suppressor of the sAPPalpha pathway in primates.
J Biol Chem. 2005 Apr 1;280(13):12548-58. Epub 2005 Jan 12.
PMID: 15647266 [PubMed - indexed for MEDLINE]

55: Kaeberlein M, Kennedy BK.
Large-scale identification in yeast of conserved ageing genes.
Mech Ageing Dev. 2005 Jan;126(1):17-21. Review.
PMID: 15610758 [PubMed - indexed for MEDLINE]

56: Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI.
Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that
are rescued by antioxidant treatment.
Free Radic Biol Med. 2005 Jan 15;38(2):258-61.
PMID: 15607908 [PubMed - indexed for MEDLINE]

57: Jenkins NL, McColl G, Lithgow GJ.
Fitness cost of extended lifespan in Caenorhabditis elegans.
Proc Biol Sci. 2004 Dec 7;271(1556):2523-6.
PMID: 15590605 [PubMed - indexed for MEDLINE]

58: Martin GM.
Genes, rates of aging, and duration of human life.
Am J Med. 2004 Dec 1;117(11):882-3. No abstract available.
PMID: 15589498 [PubMed - indexed for MEDLINE]

59: Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS.
Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor
protein carboxy terminal fragment-associated cytotoxicity.
J Neurochem. 2004 Dec;91(6):1312-21.
PMID: 15584908 [PubMed - indexed for MEDLINE]

60: Gill MS, Held JM, Fisher AL, Gibson BW, Lithgow GJ.
Lipophilic regulator of a developmental switch in Caenorhabditis elegans.
Aging Cell. 2004 Dec;3(6):413-21.
PMID: 15569358 [PubMed - indexed for MEDLINE]

61: Fuller SS, Revere D, Bugni PF, Martin GM.
A knowledgebase system to enhance scientific discovery: Telemakus.
Biomed Digit Libr. 2004 Sep 21;1(1):2.
PMID: 15507158 [PubMed - as supplied by publisher]

62: Melov S, Hubbard A.
Microarrays as a tool to investigate the biology of aging: a retrospective and
a look to the future.
Sci Aging Knowledge Environ. 2004 Oct 20;2004(42):re7. Review.
PMID: 15498758 [PubMed - indexed for MEDLINE]

63: Kaeberlein M.
Aging-related research in the "-omics" age.
Sci Aging Knowledge Environ. 2004 Oct 20;2004(42):pe39. Review.
PMID: 15498757 [PubMed - indexed for MEDLINE]

64: Lopez MF, Melov S, Johnson F, Nagulko N, Golenko E, Kuzdzal S, Ackloo S,
Mikulskis A.
Proteomic analysis of mitochondrial proteins.
Int Rev Neurobiol. 2004;61:31-48. Review. No abstract available.
PMID: 15482810 [PubMed - indexed for MEDLINE]

65: Melov S.
Modeling mitochondrial function in aging neurons.
Trends Neurosci. 2004 Oct;27(10):601-6. Review.
PMID: 15374671 [PubMed - indexed for MEDLINE]

66: Revere D, Fuller S, Bugni PF, Martin GM.
An information extraction and representation system for rapid review of the
biomedical literature.
Medinfo. 2004;11(Pt 2):788-92.
PMID: 15360920 [PubMed - indexed for MEDLINE]

67: Kaeberlein M, Kirkland KT, Fields S, Kennedy BK.
Sir2-independent life span extension by calorie restriction in yeast.
PLoS Biol. 2004 Sep;2(9):E296. Epub 2004 Aug 24.
PMID: 15328540 [PubMed - indexed for MEDLINE]

68: Lopez MF, Mikulskis A, Golenko E, Melov S, Bennett D, Cherkasskiy A,
Kuzdzal S, Kramer S, Sissors D.
Microscale fractionation facilitates detection of differentially expressed
proteins in Alzheimer's disease brain samples.
Electrophoresis. 2004 Aug;25(15):2557-63. Erratum in: Electrophoresis. 2004
Oct;25(18-19):3322.
PMID: 15300776 [PubMed - indexed for MEDLINE]

69: Martin GM.
New opportunities for genetic approaches to aging research using Roy Walford's
favorite animal.
Exp Gerontol. 2004 Jun;39(6):913-6. No abstract available.
PMID: 15217690 [PubMed - indexed for MEDLINE]

70: Sampayo JN, Lithgow GJ.
S.W.A.T.--SOD weapons and tactics.
Sci Aging Knowledge Environ. 2004 Jun 23;2004(25):pe27.
PMID: 15215539 [PubMed - indexed for MEDLINE]

71: Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E,
Kennedy BK.
A-type lamins regulate retinoblastoma protein function by promoting subnuclear
localization and preventing proteasomal degradation.
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9677-82. Epub 2004 Jun 21.
PMID: 15210943 [PubMed - indexed for MEDLINE]

72: Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami
A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik
RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL,
West MD, Wilmoth JR, Wright WE.
The aging factor in health and disease: the promise of basic research on aging.
Aging Clin Exp Res. 2004 Apr;16(2):104-11; discussion 111-2. Review. No abstract
available.
PMID: 15195984 [PubMed - indexed for MEDLINE]

73: Martin GM, Loeb LA.
Ageing: mice and mitochondria.
Nature. 2004 May 27;429(6990):357-9. No abstract available.
PMID: 15164048 [PubMed - indexed for MEDLINE]

74: Golden TR, Melov S.
Microarray analysis of gene expression with age in individual nematodes.
Aging Cell. 2004 Jun;3(3):111-24.
PMID: 15153179 [PubMed - indexed for MEDLINE]

75: Kaeberlein M, Andalis AA, Liszt GB, Fink GR, Guarente L.
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent
mechanism.
Genetics. 2004 Apr;166(4):1661-72.
PMID: 15126388 [PubMed - indexed for MEDLINE]

76: Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doctrow SR, Harry J,
Melov S.
Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic
analysis, specific respiratory chain defects, and efficacious antioxidant
therapy in superoxide dismutase 2 null mice.
J Neurochem. 2004 Feb;88(3):657-67.
PMID: 14720215 [PubMed - indexed for MEDLINE]

77: Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E,
Kennedy BK.
Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.
Mol Cell Biol. 2004 Jan;24(2):595-607.
PMID: 14701733 [PubMed - indexed for MEDLINE]

78: Wang B, Hu Q, Hearn MG, Shimizu K, Ware CB, Liggitt DH, Jin LW, Cool BH,
Storm DR, Martin GM.
Isoform-specific knockout of FE65 leads to impaired learning and memory.
J Neurosci Res. 2004 Jan 1;75(1):12-24.
PMID: 14689444 [PubMed - indexed for MEDLINE]

79: Sampayo JN, Olsen A, Lithgow GJ.
Oxidative stress in Caenorhabditis elegans: protective effects of superoxide
dismutase/catalase mimetics.
Aging Cell. 2003 Dec;2(6):319-26.
PMID: 14677634 [PubMed - indexed for MEDLINE]

80: Sampayo JN, Gill MS, Lithgow GJ.
Oxidative stress and aging--the use of superoxide dismutase/catalase mimetics
to extend lifespan.
Biochem Soc Trans. 2003 Dec;31(Pt 6):1305-7. Review.
PMID: 14641049 [PubMed - indexed for MEDLINE]

81: Martin GM.
Help wanted: physiologists for research on aging.
Sci Aging Knowledge Environ. 2002 Mar 6;2002(9):vp2. No abstract available.
PMID: 14603030 [PubMed - indexed for MEDLINE]

82: Melov S.
Spotlight on nematode mitochondria in RNAi mega-screen.
Sci Aging Knowledge Environ. 2002 Nov 27;2002(47):pe18.
PMID: 14603016 [PubMed - indexed for MEDLINE]

83: Martin GM.
SAGE KE: an intellectual home for scientists who seek to understand why and how
organisms age.
Sci Aging Knowledge Environ. 2001 Oct 3;2001(1):vp2. No abstract available.
PMID: 14602954 [PubMed - indexed for MEDLINE]

84: Kaeberlein M, McVey M, Guarente L.
Using yeast to discover the fountain of youth.
Sci Aging Knowledge Environ. 2001 Oct 3;2001(1):pe1. Review.
PMID: 14602950 [PubMed - indexed for MEDLINE]

85: Samper E, Nicholls DG, Melov S.
Mitochondrial oxidative stress causes chromosomal instability of mouse
embryonic fibroblasts.
Aging Cell. 2003 Oct;2(5):277-85. Erratum in: Aging Cell. 2003 Dec;2(6):343.
PMID: 14570235 [PubMed - indexed for MEDLINE]

86: Gill MS, Olsen A, Sampayo JN, Lithgow GJ.
An automated high-throughput assay for survival of the nematode Caenorhabditis
elegans.
Free Radic Biol Med. 2003 Sep 15;35(6):558-65.
PMID: 12957648 [PubMed - indexed for MEDLINE]

87: Chen L, Lee L, Kudlow BA, Dos Santos HG, Sletvold O, Shafeghati Y, Botha
EG, Garg A, Hanson NB, Martin GM, Mian IS, Kennedy BK, Oshima J.
LMNA mutations in atypical Werner's syndrome.
Lancet. 2003 Aug 9;362(9382):440-5.
PMID: 12927431 [PubMed - indexed for MEDLINE]

88: Muriel JM, Brannan M, Taylor K, Johnstone IL, Lithgow GJ, Tuckwell D.
M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer
body shape.
Dev Biol. 2003 Aug 15;260(2):339-51.
PMID: 12921736 [PubMed - indexed for MEDLINE]

89: Golden TR, Hinerfeld DA, Melov S.
Oxidative stress and aging: beyond correlation.
Aging Cell. 2002 Dec;1(2):117-23. Review.
PMID: 12882341 [PubMed - indexed for MEDLINE]

90: Walker GA, Lithgow GJ.
Lifespan extension in C. elegans by a molecular chaperone dependent upon
insulin-like signals.
Aging Cell. 2003 Apr;2(2):131-9.
PMID: 12882326 [PubMed - indexed for MEDLINE]

91: Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J.
Oxygen sensitivity severely limits the replicative lifespan of murine
fibroblasts.
Nat Cell Biol. 2003 Aug;5(8):741-7. Erratum in: Nat Cell Biol. 2003
Sep;5(9):839.
PMID: 12855956 [PubMed - indexed for MEDLINE]

92: Lithgow GJ.
Does anti-aging equal anti-microbial?
Sci Aging Knowledge Environ. 2003 Jun 25;2003(25):PE16.
PMID: 12844540 [PubMed - indexed for MEDLINE]

93: Mansour AA, Babstock DM, Penney JH, Martin GM, McLean JH, Harley CW.
Novel objects in a holeboard probe the role of the locus coeruleus in
curiosity: support for two modes of attention in the rat.
Behav Neurosci. 2003 Jun;117(3):621-31.
PMID: 12802890 [PubMed - indexed for MEDLINE]

94: Howse DJ, Squires AS, Martin GM, Skinner DM.
Perirhinal cortex lesions impair context aversion learning.
Learn Mem. 2003 May-Jun;10(3):161-7.
PMID: 12773580 [PubMed - indexed for MEDLINE]

95: Lagunoff D, Martin GM.
Earl Philip Benditt, April 15, 1916 - May 27, 1996.
Biogr Mem Natl Acad Sci. 2002;81:24-46. No abstract available.
PMID: 12661553 [PubMed - indexed for MEDLINE]

96: Nair PN, Golden T, Melov S.
Microarray workshop on aging.
Mech Ageing Dev. 2003 Jan;124(1):133-8.
PMID: 12618016 [PubMed - indexed for MEDLINE]

97: Martin GM, LaMarco K, Strauss E, L Kelner K.
Research on aging: the end of the beginning.
Science. 2003 Feb 28;299(5611):1339-41. No abstract available.
PMID: 12610292 [PubMed - indexed for MEDLINE]

98: Skinner DM, Etchegary CM, Ekert-Maret EC, Baker CJ, Harley CW, Evans JH,
Martin GM.
An analysis of response, direction, and place learning in an open field and T
maze.
J Exp Psychol Anim Behav Process. 2003 Jan;29(1):3-13.
PMID: 12561129 [PubMed - indexed for MEDLINE]

99: Lithgow GJ, Gill MS.
Physiology: Cost-free longevity in mice?
Nature. 2003 Jan 9;421(6919):125-6. No abstract available.
PMID: 12520289 [PubMed - indexed for MEDLINE]

100: Martin GM.
The evolutionary substrate of aging.
Arch Neurol. 2002 Nov;59(11):1702-5. Review. No abstract available.
PMID: 12433253 [PubMed - indexed for MEDLINE]

101: Maezawa I, Wang B, Hu Q, Martin GM, Jin LW, Oshima J.
Alterations of chaperone protein expression in presenilin mutant neurons in
response to glutamate excitotoxicity.
Pathol Int. 2002 Sep;52(9):551-4.
PMID: 12406183 [PubMed - indexed for MEDLINE]

102: Martin GM.
Gene action in the aging brain: an evolutionary biological perspective.
Neurobiol Aging. 2002 Sep-Oct;23(5):647-54. Review.
PMID: 12392765 [PubMed - indexed for MEDLINE]

103: Zitnik G, Martin GM.
Age-related decline in neurogenesis: old cells or old environment?
J Neurosci Res. 2002 Nov 1;70(3):258-63. Review. No abstract available.
PMID: 12391584 [PubMed - indexed for MEDLINE]

104: Kaeberlein M, Andalis AA, Fink GR, Guarente L.
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism
related to calorie restriction.
Mol Cell Biol. 2002 Nov;22(22):8056-66.
PMID: 12391171 [PubMed - indexed for MEDLINE]

105: Jin LW, Hua DH, Shie FS, Maezawa I, Sopher B, Martin GM.
Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell
death.
J Mol Neurosci. 2002 Aug-Oct;19(1-2):57-61.
PMID: 12212794 [PubMed - indexed for MEDLINE]

106: Melov S.
Animal models of oxidative stress, aging, and therapeutic antioxidant
interventions.
Int J Biochem Cell Biol. 2002 Nov;34(11):1395-400. Review.
PMID: 12200034 [PubMed - indexed for MEDLINE]

107: Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink
GR, Guarente L.
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing
respiration.
Nature. 2002 Jul 18;418(6895):344-8.
PMID: 12124627 [PubMed - indexed for MEDLINE]

108: Astur RS, Klein RL, Mumby DG, Protz DK, Sutherland RJ, Martin GM.
A role for olfaction in object recognition by normal and hippocampal-damaged
rats.
Neurobiol Learn Mem. 2002 Jul;78(1):186-91.
PMID: 12071675 [PubMed - indexed for MEDLINE]

109: Kaeberlein M, Jegalian B, McVey M.
AGEID: a database of aging genes and interventions.
Mech Ageing Dev. 2002 Apr 30;123(8):1115-9.
PMID: 12044961 [PubMed - indexed for MEDLINE]

110: Melov S.
Therapeutics against mitochondrial oxidative stress in animal models of aging.
Ann N Y Acad Sci. 2002 Apr;959:330-40. Review.
PMID: 11976207 [PubMed - indexed for MEDLINE]

111: Armstrong CM, Kaeberlein M, Imai SI, Guarente L.
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects
on in vivo silencing phenotypes and in vitro histone deacetylation activity.
Mol Biol Cell. 2002 Apr;13(4):1427-38.
PMID: 11950950 [PubMed - indexed for MEDLINE]

112: Lopez MF, Melov S.
Applied proteomics: mitochondrial proteins and effect on function.
Circ Res. 2002 Mar 8;90(4):380-9. Review.
PMID: 11884366 [PubMed - indexed for MEDLINE]

113: Lithgow GJ, Walker GA.
Stress resistance as a determinate of C. elegans lifespan.
Mech Ageing Dev. 2002 Apr;123(7):765-71. Review.
PMID: 11869734 [PubMed - indexed for MEDLINE]

114: Singh NP, Ogburn CE, Wolf NS, van Belle G, Martin GM.
DNA double-strand breaks in mouse kidney cells with age.
Biogerontology. 2001;2(4):261-70.
PMID: 11868901 [PubMed - indexed for MEDLINE]

115: Hu Q, Cool BH, Wang B, Hearn MG, Martin GM.
A candidate molecular mechanism for the association of an intronic polymorphism
of FE65 with resistance to very late onset dementia of the Alzheimer type.
Hum Mol Genet. 2002 Feb 15;11(4):465-75.
PMID: 11854179 [PubMed - indexed for MEDLINE]

116: Melov S.
'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease.
Trends Neurosci. 2002 Mar;25(3):121-3; discussion 123-4. Review.
PMID: 11852134 [PubMed - indexed for MEDLINE]

117: Kennedy BK.
Mammalian transcription factors in yeast: strangers in a familiar land.
Nat Rev Mol Cell Biol. 2002 Jan;3(1):41-9. Review.
PMID: 11823797 [PubMed - indexed for MEDLINE]

118: Nihei N, Kouprina N, Larionov V, Oshima J, Martin GM, Ichikawa T, Barrett
JC.
Functional evidence for a metastasis suppressor gene for rat prostate cancer
within a 60-kilobase region on human chromosome 8p21-p12.
Cancer Res. 2002 Jan 15;62(2):367-70.
PMID: 11809681 [PubMed - indexed for MEDLINE]

119: Kaeberlein M, Guarente L.
Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote
cell wall integrity.
Genetics. 2002 Jan;160(1):83-95.
PMID: 11805047 [PubMed - indexed for MEDLINE]

120: Tissenbaum HA, Guarente L.
Model organisms as a guide to mammalian aging.
Dev Cell. 2002 Jan;2(1):9-19. Review.
PMID: 11782310 [PubMed - indexed for MEDLINE]

121: Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Miller MW,
Ware CB, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ.
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is
associated with reduced clearance of hippocampal memory traces.
Neuron. 2001 Dec 6;32(5):911-26. Erratum in: Neuron 2002 Jan 17;33(2):313.
PMID: 11738035 [PubMed - indexed for MEDLINE]

122: Martin GM.
Keynote: mechanisms of senescence--complificationists versus
simplificationists.
Mech Ageing Dev. 2002 Jan;123(2-3):65-73; discussion 75-9. Review.
PMID: 11718800 [PubMed - indexed for MEDLINE]

123: Ogburn CE, Carlberg K, Ottinger MA, Holmes DJ, Martin GM, Austad SN.
Exceptional cellular resistance to oxidative damage in long-lived birds
requires active gene expression.
J Gerontol A Biol Sci Med Sci. 2001 Nov;56(11):B468-74.
PMID: 11682567 [PubMed - indexed for MEDLINE]

124: Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman
K, Wallace DC, Malfroy B.
Lifespan extension and rescue of spongiform encephalopathy in superoxide
dismutase 2 nullizygous mice treated with superoxide dismutase-catalase
mimetics.
J Neurosci. 2001 Nov 1;21(21):8348-53.
PMID: 11606622 [PubMed - indexed for MEDLINE]

125: Martin GM.
Frontiers of aging.
Science. 2001 Oct 5;294(5540):13. No abstract available.
PMID: 11588222 [PubMed - indexed for MEDLINE]

126: Golden TR, Melov S.
Mitochondrial DNA mutations, oxidative stress, and aging.
Mech Ageing Dev. 2001 Sep 30;122(14):1577-89.
PMID: 11511398 [PubMed - indexed for MEDLINE]

127: Lithgow GJ.
Hormesis--a new hope for ageing studies or a poor second to genetics?
Hum Exp Toxicol. 2001 Jun;20(6):301-3; discussion 319-20. No abstract available.

PMID: 11506284 [PubMed - indexed for MEDLINE]

128: Kennedy BK, Liu OW, Dick FA, Dyson N, Harlow E, Vidal M.
Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs
independently of interaction through the LXCXE binding cleft.
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8720-5. Epub 2001 Jul 10.
PMID: 11447271 [PubMed - indexed for MEDLINE]

129: Walker GA, White TM, McColl G, Jenkins NL, Babich S, Candido EP, Johnson
TE, Lithgow GJ.
Heat shock protein accumulation is upregulated in a long-lived mutant of
Caenorhabditis elegans.
J Gerontol A Biol Sci Med Sci. 2001 Jul;56(7):B281-7.
PMID: 11445592 [PubMed - indexed for MEDLINE]

130: Huxter JR, Thorpe CM, Martin GM, Harley CW.
Spatial problem solving and hippocampal place cell firing in rats: control by
an internal sense of direction carried across environments.
Behav Brain Res. 2001 Aug 27;123(1):37-48.
PMID: 11377728 [PubMed - indexed for MEDLINE]

131: Harley CW, Martin GM, Skinner DM, Squires A.
The moving fire hydrant experiment: movement of objects to a new location
reelicits marking in rats.
Neurobiol Learn Mem. 2001 May;75(3):303-9.
PMID: 11300736 [PubMed - indexed for MEDLINE]

132: McVey M, Kaeberlein M, Tissenbaum HA, Guarente L.
The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a
composite of normal aging processes and mitotic arrest due to defective
recombination.
Genetics. 2001 Apr;157(4):1531-42.
PMID: 11290710 [PubMed - indexed for MEDLINE]

133: Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC,
Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE.
RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of
retinoblastoma tumor suppressor family proteins found in limited discrete
regions of the nucleus at growth arrest.
Mol Cell Biol. 2001 Apr;21(8):2918-32.
PMID: 11283269 [PubMed - indexed for MEDLINE]

134: Stevenson LF, Kennedy BK, Harlow E.
A large-scale overexpression screen in Saccharomyces cerevisiae identifies
previously uncharacterized cell cycle genes.
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3946-51.
PMID: 11274415 [PubMed - indexed for MEDLINE]

135: Barsyte D, Lovejoy DA, Lithgow GJ.
Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of
Caenorhabditis elegans.
FASEB J. 2001 Mar;15(3):627-34.
PMID: 11259381 [PubMed - indexed for MEDLINE]

136: Skinner DM, Martin GM, Scanlon CJ, Thorpe CM, Barry J, Evans JH, Harley
CW.
A two-platform task reveals a deficit in the ability of rats to return to the
start location in the water maze.
Behav Neurosci. 2001 Feb;115(1):220-8.
PMID: 11256445 [PubMed - indexed for MEDLINE]

137: Tissenbaum HA, Guarente L.
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
Nature. 2001 Mar 8;410(6825):227-30.
PMID: 11242085 [PubMed - indexed for MEDLINE]

138: Melov S, Dodge V.
The Buck Institute for age research.
Exp Gerontol. 2001 Feb;36(2):205-8. No abstract available.
PMID: 11226736 [PubMed - indexed for MEDLINE]

139: Castro E, Edland SD, Lee L, Ogburn CE, Deeb SS, Brown G, Panduro A,
Riestra R, Tilvis R, Louhija J, Penttinen R, Erkkola R, Wang L, Martin GM,
Oshima J.
Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and
atherosclerosis.
Am J Med Genet. 2000 Dec 11;95(4):374-80.
PMID: 11186893 [PubMed - indexed for MEDLINE]

140: Schriner SE, Smith AC, Dang NH, Fukuchi K, Martin GM.
Overexpression of wild-type and nuclear-targeted catalase modulates resistance
to oxidative stress but does not alter spontaneous mutant frequencies at APRT.
Mutat Res. 2000 Apr 3;449(1-2):21-31.
PMID: 10751631 [PubMed - indexed for MEDLINE]

141: Martin GM, Bressler SL.
Transcriptional infidelity in aging cells and its relevance for the Orgel
hypothesis.
Neurobiol Aging. 2000 Nov-Dec;21(6):897-900; discussion 903-4. No abstract
available.
PMID: 11124438 [PubMed - indexed for MEDLINE]

142: Kennedy BK, Barbie DA, Classon M, Dyson N, Harlow E.
Nuclear organization of DNA replication in primary mammalian cells.
Genes Dev. 2000 Nov 15;14(22):2855-68.
PMID: 11090133 [PubMed - indexed for MEDLINE]

143: Martin GM, Oshima J.
Lessons from human progeroid syndromes.
Nature. 2000 Nov 9;408(6809):263-6. Review.
PMID: 11089984 [PubMed - indexed for MEDLINE]

144: Schriner SE, Ogburn CE, Smith AC, Newcomb TG, Ladiges WC, Dolle ME, Vijg
J, Fukuchi K, Martin GM.
Levels of dna damage are unaltered in mice overexpressing human catalase in
nuclei.
Free Radic Biol Med. 2000 Oct 1;29(7):664-73.
PMID: 11033419 [PubMed - indexed for MEDLINE]

145: Classon M, Kennedy BK, Mulloy R, Harlow E.
Opposing roles of pRB and p107 in adipocyte differentiation.
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10826-31.
PMID: 10995476 [PubMed - indexed for MEDLINE]

146: Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow
E.
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone
gene transcription.
Genes Dev. 2000 Sep 15;14(18):2283-97.
PMID: 10995386 [PubMed - indexed for MEDLINE]

147: Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace
DC, Malfroy B, Doctrow SR, Lithgow GJ.
Extension of life-span with superoxide dismutase/catalase mimetics.
Science. 2000 Sep 1;289(5484):1567-9.
PMID: 10968795 [PubMed - indexed for MEDLINE]

148: Martin GM.
Molecular mechanisms of late life dementias.
Exp Gerontol. 2000 Jul;35(4):439-43. Review.
PMID: 10959031 [PubMed - indexed for MEDLINE]

149: Hannan KM, Kennedy BK, Cavanaugh AH, Hannan RD, Hirschler-Laszkiewicz I,
Jefferson LS, Rothblum LI.
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA
transcription during confluence-induced cell cycle arrest.
Oncogene. 2000 Jul 20;19(31):3487-97.
PMID: 10918607 [PubMed - indexed for MEDLINE]

150: Sampayo JN, Jenkins NL, Lithgow GJ.
Using stress resistance to isolate novel longevity mutations in Caenorhabditis
elegans.
Ann N Y Acad Sci. 2000 Jun;908:324-6. No abstract available.
PMID: 10911977 [PubMed - indexed for MEDLINE]

151: McColl G, Jenkins NL, Walker DW, Lithgow GJ.
Testing evolutionary theories of aging.
Ann N Y Acad Sci. 2000 Jun;908:319-20. No abstract available.
PMID: 10911975 [PubMed - indexed for MEDLINE]

152: Melov S.
Mitochondrial oxidative stress. Physiologic consequences and potential for a
role in aging.
Ann N Y Acad Sci. 2000 Jun;908:219-25. Review.
PMID: 10911961 [PubMed - indexed for MEDLINE]

153: Martin GM.
Some new directions for research on the biology of aging.
Ann N Y Acad Sci. 2000 Jun;908:1-13. Review.
PMID: 10911942 [PubMed - indexed for MEDLINE]

154: Pultz MA, Zimmerman KK, Alto NM, Kaeberlein M, Lange SK, Pitt JN, Reeves
NL, Zehrung DL.
A genetic screen for zygotic embryonic lethal mutations affecting cuticular
morphology in the wasp Nasonia vitripennis.
Genetics. 2000 Mar;154(3):1213-29.
PMID: 10866651 [PubMed - indexed for MEDLINE]

155: Lithgow GJ.
Stress response and aging in Caenorhabditis elegans.
Results Probl Cell Differ. 2000;29:131-48. Review. No abstract available.
PMID: 10838698 [PubMed - indexed for MEDLINE]

156: Walker DW, McColl G, Jenkins NL, Harris J, Lithgow GJ.
Evolution of lifespan in C. elegans.
Nature. 2000 May 18;405(6784):296-7. No abstract available.
PMID: 10830948 [PubMed - indexed for MEDLINE]

157: Lithgow GJ, Andersen JK.
The real Dorian Gray mouse.
Bioessays. 2000 May;22(5):410-3. Review.
PMID: 10797480 [PubMed - indexed for MEDLINE]

158: Hu Q, Jin LW, Starbuck MY, Martin GM.
Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta
amyloidogenesis, in Alzheimer cerebellum and other brain regions.
J Neurosci Res. 2000 Apr 1;60(1):73-86.
PMID: 10723070 [PubMed - indexed for MEDLINE]

159: Imai S, Armstrong CM, Kaeberlein M, Guarente L.
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent
histone deacetylase.
Nature. 2000 Feb 17;403(6771):795-800.
PMID: 10693811 [PubMed - indexed for MEDLINE]

160: Wang L, Evans AE, Ogburn CE, Youssoufian H, Martin GM, Oshima J.
Werner helicase expression in human fetal and adult aortas.
Exp Gerontol. 1999 Dec;34(8):935-41.
PMID: 10673147 [PubMed - indexed for MEDLINE]

161: Hynes CA, Martin GM, Harley CW, Huxter JR, Evans JH.
Multiple points of entry into a circular enclosure prevent place learning
despite normal vestibular orientation and cue arrays: evidence for map
resetting.
J Exp Psychol Anim Behav Process. 2000 Jan;26(1):64-73.
PMID: 10650544 [PubMed - indexed for MEDLINE]

162: Melov S, Schneider JA, Coskun PE, Bennett DA, Wallace DC.
Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA.
Neurobiol Aging. 1999 Sep-Oct;20(5):565-71.
PMID: 10638530 [PubMed - indexed for MEDLINE]

163: Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ.
P13-kinase inhibition induces dauer formation, thermotolerance and longevity in
C. elegans.
Neurobiol Aging. 1999 Sep-Oct;20(5):513-9.
PMID: 10638524 [PubMed - indexed for MEDLINE]

164: Wang L, Ogburn CE, Ware CB, Ladiges WC, Youssoufian H, Martin GM, Oshima
J.
Cellular Werner phenotypes in mice expressing a putative dominant-negative
human WRN gene.
Genetics. 2000 Jan;154(1):357-62.
PMID: 10628995 [PubMed - indexed for MEDLINE]

165: Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G.
A common muscarinic pathway for diapause recovery in the distantly related
nematode species Caenorhabditis elegans and Ancylostoma caninum.
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):460-5.
PMID: 10618440 [PubMed - indexed for MEDLINE]

166: Martin GM.
APOE alleles and lipophylic pathogens.
Neurobiol Aging. 1999 Jul-Aug;20(4):441-3. Review. No abstract available.
PMID: 10604437 [PubMed - indexed for MEDLINE]

167: Hu Q, Hearn MG, Jin LW, Bressler SL, Martin GM.
Alternatively spliced isoforms of FE65 serve as neuron-specific and
non-neuronal markers.
J Neurosci Res. 1999 Dec 1;58(5):632-40.
PMID: 10561691 [PubMed - indexed for MEDLINE]

168: Harley CW, Martin GM.
Open field motor patterns and object marking, but not object sniffing, are
altered by ibotenate lesions of the hippocampus.
Neurobiol Learn Mem. 1999 Nov;72(3):202-14.
PMID: 10536098 [PubMed - indexed for MEDLINE]

169: Kaeberlein M, McVey M, Guarente L.
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces
cerevisiae by two different mechanisms.
Genes Dev. 1999 Oct 1;13(19):2570-80.
PMID: 10521401 [PubMed - indexed for MEDLINE]

170: Melov S, Coskun PE, Wallace DC.
Mouse models of mitochondrial disease, oxidative stress, and senescence.
Mutat Res. 1999 Jul 30;434(3):233-42. Review.
PMID: 10486594 [PubMed - indexed for MEDLINE]

171: Martin GM, Oshima J, Gray MD, Poot M.
What geriatricians should know about the Werner syndrome.
J Am Geriatr Soc. 1999 Sep;47(9):1136-44. Review. No abstract available.
PMID: 10484259 [PubMed - indexed for MEDLINE]

172: Prince PR, Ogburn CE, Moser MJ, Emond MJ, Martin GM, Monnat RJ Jr.
Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner
syndrome fibroblast cell lines.
Hum Genet. 1999 Jul-Aug;105(1-2):132-8.
PMID: 10480367 [PubMed - indexed for MEDLINE]

173: Balajee AS, Machwe A, May A, Gray MD, Oshima J, Martin GM, Nehlin JO,
Brosh R, Orren DK, Bohr VA.
The Werner syndrome protein is involved in RNA polymerase II transcription.
Mol Biol Cell. 1999 Aug;10(8):2655-68.
PMID: 10436020 [PubMed - indexed for MEDLINE]

174: Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, Silver PA, Keil
RL, Guarente L.
Elimination of replication block protein Fob1 extends the life span of yeast
mother cells.
Mol Cell. 1999 Apr;3(4):447-55.
PMID: 10230397 [PubMed - indexed for MEDLINE]

175: Esposito LA, Melov S, Panov A, Cottrell BA, Wallace DC.
Mitochondrial disease in mouse results in increased oxidative stress.
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4820-5.
PMID: 10220377 [PubMed - indexed for MEDLINE]

176: Guo Q, Sebastian L, Sopher BL, Miller MW, Glazner GW, Ware CB, Martin GM,
Mattson MP.
Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic
fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative
cascades promoted by a PS1 mutation.
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4125-30.
PMID: 10097174 [PubMed - indexed for MEDLINE]

177: Castro E, Ogburn CE, Hunt KE, Tilvis R, Louhija J, Penttinen R, Erkkola R,
Panduro A, Riestra R, Piussan C, Deeb SS, Wang L, Edland SD, Martin GM, Oshima
J.
Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic
variability of 1367Cys/Arg, and its stability in a population of Finnish
centenarians.
Am J Med Genet. 1999 Feb 19;82(5):399-403.
PMID: 10069711 [PubMed - indexed for MEDLINE]

178: Guo Q, Sebastian L, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.
Increased vulnerability of hippocampal neurons from presenilin-1 mutant
knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide
production and caspase activation.
J Neurochem. 1999 Mar;72(3):1019-29.
PMID: 10037473 [PubMed - indexed for MEDLINE]

179: Melov S, Coskun P, Patel M, Tuinstra R, Cottrell B, Jun AS, Zastawny TH,
Dizdaroglu M, Goodman SI, Huang TT, Miziorko H, Epstein CJ, Wallace DC.
Mitochondrial disease in superoxide dismutase 2 mutant mice.
Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):846-51.
PMID: 9927656 [PubMed - indexed for MEDLINE]

180: Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in
presenilin-1 mutant knock-in mice.
Nat Med. 1999 Jan;5(1):101-6.
PMID: 9883847 [PubMed - indexed for MEDLINE]

181: Jin LW, Hearn MG, Ogburn CE, Dang N, Nochlin D, Ladiges WC, Martin GM.
Transgenic mice over-expressing the C-99 fragment of betaPP with an
alpha-secretase site mutation develop a myopathy similar to human inclusion body
myositis.
Am J Pathol. 1998 Dec;153(6):1679-86.
PMID: 9846957 [PubMed - indexed for MEDLINE]

182: Hu Q, Kukull WA, Bressler SL, Gray MD, Cam JA, Larson EB, Martin GM, Deeb
SS.
The human FE65 gene: genomic structure and an intronic biallelic polymorphism
associated with sporadic dementia of the Alzheimer type.
Hum Genet. 1998 Sep;103(3):295-303.
PMID: 9799084 [PubMed - indexed for MEDLINE]

183: Martin GM.
Introduction: genetic determinants of mid- and late-life dementias.
Cell Mol Life Sci. 1998 Sep;54(9):895-6.
PMID: 9791530 [PubMed - indexed for MEDLINE]

184: Martin GM.
Atherosclerosis is the leading cause of death in the developed societies.
Am J Pathol. 1998 Oct;153(4):1319-20. Review. No abstract available.
PMID: 9777964 [PubMed - indexed for MEDLINE]

185: Walker GA, Walker DW, Lithgow GJ.
A relationship between thermotolerance and longevity in Caenorhabditis elegans.
J Investig Dermatol Symp Proc. 1998 Aug;3(1):6-10.
PMID: 9732049 [PubMed - indexed for MEDLINE]

186: Gray MD, Wang L, Youssoufian H, Martin GM, Oshima J.
Werner helicase is localized to transcriptionally active nucleoli of cycling
cells.
Exp Cell Res. 1998 Aug 1;242(2):487-94.
PMID: 9683536 [PubMed - indexed for MEDLINE]

187: Wang L, Hunt KE, Martin GM, Oshima J.
Structure and function of the human Werner syndrome gene promoter: evidence for
transcriptional modulation.
Nucleic Acids Res. 1998 Aug 1;26(15):3480-5.
PMID: 9671808 [PubMed - indexed for MEDLINE]

188: Walker GA, Walker DW, Lithgow GJ.
Genes that determine both thermotolerance and rate of aging in Caenorhabditis
elegans.
Ann N Y Acad Sci. 1998 Jun 30;851:444-9. No abstract available.
PMID: 9668638 [PubMed - indexed for MEDLINE]

189: Martin GM.
The genetics of aging.
Aging (Milano). 1998 Apr;10(2):148-9. No abstract available.
PMID: 9666201 [PubMed - indexed for MEDLINE]

190: Martin GM, Wang E.
Aging andlongevity: towards the next millennium. The Bat Sheva Le Rothschild
International Seminar on Cellular, Molecular and Genetic Aspects of Aging and
Longevity. Zichron Yaacov, Israel, 7-12 December 1997.
Mol Med Today. 1998 Apr;4(4):145. No abstract available.
PMID: 9660652 [PubMed - indexed for MEDLINE]

191: Lithgow GJ.
Aging mechanisms from nematodes to mammals.
Nutrition. 1998 Jun;14(6):522-4. Review. No abstract available.
PMID: 9646294 [PubMed - indexed for MEDLINE]

192: Wallace DC, Melov S.
Radicals r'aging.
Nat Genet. 1998 Jun;19(2):105-6. No abstract available.
PMID: 9620757 [PubMed - indexed for MEDLINE]

193: Wallace DC, Brown MD, Melov S, Graham B, Lott M.
Mitochondrial biology, degenerative diseases and aging.
Biofactors. 1998;7(3):187-90. Review. No abstract available.
PMID: 9568243 [PubMed - indexed for MEDLINE]

194: Kukull WA, Martin GM.
APOE polymorphisms and late-onset Alzheimer disease: the importance of
ethnicity.
JAMA. 1998 Mar 11;279(10):788-9. No abstract available.
PMID: 9508157 [PubMed - indexed for MEDLINE]

195: Tissenbaum HA, Ruvkun G.
An insulin-like signaling pathway affects both longevity and reproduction in
Caenorhabditis elegans.
Genetics. 1998 Feb;148(2):703-17.
PMID: 9504918 [PubMed - indexed for MEDLINE]

196: Melov S, Schneider JA, Day BJ, Hinerfeld D, Coskun P, Mirra SS, Crapo JD,
Wallace DC.
A novel neurological phenotype in mice lacking mitochondrial manganese
superoxide dismutase.
Nat Genet. 1998 Feb;18(2):159-63.
PMID: 9462746 [PubMed - indexed for MEDLINE]

197: Martin GM.
Genetics and the pathobiology of ageing.
Philos Trans R Soc Lond B Biol Sci. 1997 Dec 29;352(1363):1773-80. Review.
PMID: 9460060 [PubMed - indexed for MEDLINE]

198: Ogburn CE, Oshima J, Poot M, Chen R, Hunt KE, Gollahon KA, Rabinovitch PS,
Martin GM.
An apoptosis-inducing genotoxin differentiates heterozygotic carriers for
Werner helicase mutations from wild-type and homozygous mutants.
Hum Genet. 1997 Dec;101(2):121-5.
PMID: 9402954 [PubMed - indexed for MEDLINE]

199: Martin GM, Mian IS.
Ageing. New mice for old questions.
Nature. 1997 Nov 6;390(6655):18-9. No abstract available.
PMID: 9363884 [PubMed - indexed for MEDLINE]

200: Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun
G.
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and
longevity signals in C. elegans.
Nature. 1997 Oct 30;389(6654):994-9.
PMID: 9353126 [PubMed - indexed for MEDLINE]

201: Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL, Martin GM, Oshima J,
Loeb LA.
The Werner syndrome protein is a DNA helicase.
Nat Genet. 1997 Sep;17(1):100-3.
PMID: 9288107 [PubMed - indexed for MEDLINE]

202: Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G.
daf-2, an insulin receptor-like gene that regulates longevity and diapause in
Caenorhabditis elegans.
Science. 1997 Aug 15;277(5328):942-6.
PMID: 9252323 [PubMed - indexed for MEDLINE]

203: Gotta M, Strahl-Bolsinger S, Renauld H, Laroche T, Kennedy BK, Grunstein
M, Gasser SM.
Localization of Sir2p: the nucleolus as a compartment for silent information
regulators.
EMBO J. 1997 Jun 2;16(11):3243-55.
PMID: 9214640 [PubMed - indexed for MEDLINE]

204: Martin GM.
The Werner mutation: does it lead to a "public" or "private" mechanism of
aging?
Mol Med. 1997 Jun;3(6):356-8. Review. No abstract available.
PMID: 9234240 [PubMed - indexed for MEDLINE]

205: Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP.
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by
trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and
oxyradicals.
J Neurosci. 1997 Jun 1;17(11):4212-22.
PMID: 9151738 [PubMed - indexed for MEDLINE]

206: Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM,
Laroche T, Gasser SM, Guarente L.
Redistribution of silencing proteins from telomeres to the nucleolus is
associated with extension of life span in S. cerevisiae.
Cell. 1997 May 2;89(3):381-91.
PMID: 9150138 [PubMed - indexed for MEDLINE]

207: Martin GM, Harley CW, Smith AR, Hoyles ES, Hynes CA.
Spatial disorientation blocks reliable goal location on a plus maze but does
not prevent goal location in the Morris maze.
J Exp Psychol Anim Behav Process. 1997 Apr;23(2):183-93.
PMID: 9095541 [PubMed - indexed for MEDLINE]

208: Walker KA, Jennings CD, Pulliam J, Ogburn C, Martin GM, Urano M, Turker
MS.
A cell line selected for resistance to ionizing radiation exhibits cross
resistance to other genotoxic agents and a mutator phenotype for loss of
heterozygosity events.
Somat Cell Mol Genet. 1997 Mar;23(2):111-21.
PMID: 9330639 [PubMed - indexed for MEDLINE]

209: Melov S, Hinerfeld D, Esposito L, Wallace DC.
Multi-organ characterization of mitochondrial genomic rearrangements in ad
libitum and caloric restricted mice show striking somatic mitochondrial DNA
rearrangements with age.
Nucleic Acids Res. 1997 Mar 1;25(5):974-82.
PMID: 9023106 [PubMed - indexed for MEDLINE]

210: Martin GM.
The genetics of aging.
Hosp Pract (Minneap). 1997 Feb 15;32(2):47-50, 55-6, 59-61 passim. Review.
PMID: 9040422 [PubMed - indexed for MEDLINE]

211: Ye L, Miki T, Nakura J, Oshima J, Kamino K, Rakugi H, Ikegami H, Higaki J,
Edland SD, Martin GM, Ogihara T.
Association of a polymorphic variant of the Werner helicase gene with
myocardial infarction in a Japanese population.
Am J Med Genet. 1997 Feb 11;68(4):494-8. Erratum in: Am J Med Genet 1997 May
2;70(1):103.
PMID: 9021029 [PubMed - indexed for MEDLINE]

212: Yu CE, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu
YH, Mulligan J, Martin GM, Schellenberg GD.
Mutations in the consensus helicase domains of the Werner syndrome gene.
Werner's Syndrome Collaborative Group.
Am J Hum Genet. 1997 Feb;60(2):330-41.
PMID: 9012406 [PubMed - indexed for MEDLINE]

213: Boursnell ME, Entwisle C, Blakeley D, Roberts C, Duncan IA, Chisholm SE,
Martin GM, Jennings R, Ni Challanain D, Sobek I, Inglis SC, McLean CS.
A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides
effective protection against primary and recurrent HSV-2 disease.
J Infect Dis. 1997 Jan;175(1):16-25.
PMID: 8985191 [PubMed - indexed for MEDLINE]

214: Guo Q, Furukawa K, Sopher BL, Pham DG, Xie J, Robinson N, Martin GM,
Mattson MP.
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12
cells to death induced by amyloid beta-peptide.
Neuroreport. 1996 Dec 20;8(1):379-83.
PMID: 9051814 [PubMed - indexed for MEDLINE]

215: Marshall SE, Cobbold SP, Davies JD, Martin GM, Phillips JM, Waldmann H.
Tolerance and suppression in a primed immune system.
Transplantation. 1996 Dec 15;62(11):1614-21.
PMID: 8970617 [PubMed - indexed for MEDLINE]

216: Oshima J, Yu CE, Piussan C, Klein G, Jabkowski J, Balci S, Miki T, Nakura
J, Ogihara T, Ells J, Smith M, Melaragno MI, Fraccaro M, Scappaticci S, Matthews
J, Ouais S, Jarzebowicz A, Schellenberg GD, Martin GM.
Homozygous and compound heterozygous mutations at the Werner syndrome locus.
Hum Mol Genet. 1996 Dec;5(12):1909-13.
PMID: 8968742 [PubMed - indexed for MEDLINE]

217: Johnson TE, Lithgow GJ, Murakami S.
Hypothesis: interventions that increase the response to stress offer the
potential for effective life prolongation and increased health.
J Gerontol A Biol Sci Med Sci. 1996 Nov;51(6):B392-5.
PMID: 8914487 [PubMed - indexed for MEDLINE]

218: Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M,
Mattson MP.
Increased activity-regulating and neuroprotective efficacy of
alpha-secretase-derived secreted amyloid precursor protein conferred by a
C-terminal heparin-binding domain.
J Neurochem. 1996 Nov;67(5):1882-96. Erratum in: J Neurochem 1997
Mar;68(3):1331.
PMID: 8863493 [PubMed - indexed for MEDLINE]

219: Oshima J, Brown WT, Martin GM.
No detectable mutations at Werner helicase locus in progeria.
Lancet. 1996 Oct 19;348(9034):1106. No abstract available.
PMID: 8874483 [PubMed - indexed for MEDLINE]

220: Sopher BL, Fukuchi K, Kavanagh TJ, Furlong CE, Martin GM.
Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage
in amyloid beta protein precursor-mediated cell death.
Mol Chem Neuropathol. 1996 Oct-Dec;29(2-3):153-68.
PMID: 8971693 [PubMed - indexed for MEDLINE]

221: Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB,
Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM.
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the
conserved cytoplasmic domains of the human beta-amyloid precursor protein and
its homologues with the mouse Fe65 protein.
Hum Mol Genet. 1996 Oct;5(10):1589-98.
PMID: 8894693 [PubMed - indexed for MEDLINE]

222: Lithgow GJ.
Invertebrate gerontology: the age mutations of Caenorhabditis elegans.
Bioessays. 1996 Oct;18(10):809-15. Review.
PMID: 8885718 [PubMed - indexed for MEDLINE]

223: Martin GM, Kukull WA.
Do cultural differences affect Alzheimer disease?
JAMA. 1996 Sep 25;276(12):993-5. No abstract available.
PMID: 8805736 [PubMed - indexed for MEDLINE]

224: Kennedy BK, Guarente L.
Genetic analysis of aging in Saccharomyces cerevisiae.
Trends Genet. 1996 Sep;12(9):355-9. Review.
PMID: 8855665 [PubMed - indexed for MEDLINE]

225: Nakura J, Miki T, Ye L, Mitsuda N, Zhao Y, Kihara K, Yu CE, Oshima J,
Fukuchi KI, Wijsman EM, Schellenberg GD, Martin GM, Murano S, Hashimoto K,
Fujiwara Y, Ogihara T.
Narrowing the position of the Werner syndrome locus by homozygosity
analysis-extension of homozygosity analysis.
Genomics. 1996 Aug 15;36(1):130-41.
PMID: 8812424 [PubMed - indexed for MEDLINE]

226: Morris JZ, Tissenbaum HA, Ruvkun G.
A phosphatidylinositol-3-OH kinase family member regulating longevity and
diapause in Caenorhabditis elegans.
Nature. 1996 Aug 8;382(6591):536-9.
PMID: 8700226 [PubMed - indexed for MEDLINE]

227: Lithgow GJ, Kirkwood TB.
Mechanisms and evolution of aging.
Science. 1996 Jul 5;273(5271):80. Review. No abstract available.
PMID: 8658201 [PubMed - indexed for MEDLINE]

228: Fukuchi K, Ho L, Younkin SG, Kunkel DD, Ogburn CE, LeBoeuf RC, Furlong CE,
Deeb SS, Nochlin D, Wegiel J, Wisniewski HM, Martin GM.
High levels of circulating beta-amyloid peptide do not cause cerebral
beta-amyloidosis in transgenic mice.
Am J Pathol. 1996 Jul;149(1):219-27.
PMID: 8686746 [PubMed - indexed for MEDLINE]

229: Goddard KA, Yu CE, Oshima J, Miki T, Nakura J, Piussan C, Martin GM,
Schellenberg GD, Wijsman EM.
Toward localization of the Werner syndrome gene by linkage disequilibrium and
ancestral haplotyping: lessons learned from analysis of 35 chromosome
8p11.1-21.1 markers.
Am J Hum Genet. 1996 Jun;58(6):1286-302.
PMID: 8651307 [PubMed - indexed for MEDLINE]

230: Schulz VP, Zakian VA, Ogburn CE, McKay J, Jarzebowicz AA, Edland SD,
Martin GM.
Accelerated loss of telomeric repeats may not explain accelerated replicative
decline of Werner syndrome cells.
Hum Genet. 1996 Jun;97(6):750-4.
PMID: 8641691 [PubMed - indexed for MEDLINE]

231: Fukuchi K, Ohman T, Dang N, Smith AC, Furlong CE, Martin GM.
Overexpressions of cDNAs for beta-amyloid precursor proteins 695, 751, and 770
enhance the secretion of beta-amyloid precursor protein derivatives and the
survival of P19-derived neurons.
J Neurochem. 1996 May;66(5):2201-4.
PMID: 8780054 [PubMed - indexed for MEDLINE]

232: Martin GM, Austad SN, Johnson TE.
Genetic analysis of ageing: role of oxidative damage and environmental
stresses.
Nat Genet. 1996 May;13(1):25-34. Review.
PMID: 8673100 [PubMed - indexed for MEDLINE]

233: Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura
J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD.
Positional cloning of the Werner's syndrome gene.
Science. 1996 Apr 12;272(5259):258-62.
PMID: 8602509 [PubMed - indexed for MEDLINE]

234: Martin GM.
Fak and focal adhesions.
Jpn J Cancer Res. 1996 Mar;87(3):inside front cover. Review. No abstract
available.
PMID: 8613421 [PubMed - indexed for MEDLINE]

235: Martin GM.
Somatic mutagenesis and antimutagenesis in aging research.
Mutat Res. 1996 Feb 19;350(1):35-41. Review.
PMID: 8657194 [PubMed - indexed for MEDLINE]

236: Martin GM, Ogburn CE, Colgin LM, Gown AM, Edland SD, Monnat RJ Jr.
Somatic mutations are frequent and increase with age in human kidney epithelial
cells.
Hum Mol Genet. 1996 Feb;5(2):215-21.
PMID: 8824877 [PubMed - indexed for MEDLINE]

237: Martin GM.
Genetic modulation of the senescent phenotype of Homo sapiens.
Exp Gerontol. 1996 Jan-Apr;31(1-2):49-59. Review.
PMID: 8706804 [PubMed - indexed for MEDLINE]

238: Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ,
Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ.
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese
superoxide dismutase.
Nat Genet. 1995 Dec;11(4):376-81.
PMID: 7493016 [PubMed - indexed for MEDLINE]

239: Melov S, Shoffner JM, Kaufman A, Wallace DC.
Marked increase in the number and variety of mitochondrial DNA rearrangements
in aging human skeletal muscle.
Nucleic Acids Res. 1995 Oct 25;23(20):4122-6. Erratum in: Nucleic Acids Res 1995
Dec 11;23(23):4938.
PMID: 7479075 [PubMed - indexed for MEDLINE]

240: Kellner LH, Weiner Z, Weiss RR, Neuer M, Martin GM, Mueenuddin M, Bombard
A.
Triple marker (alpha-fetoprotein, unconjugated estriol, human chorionic
gonadotropin) versus alpha-fetoprotein plus free-beta subunit in
second-trimester maternal serum screening for fetal Down syndrome: a prospective
comparison study.
Am J Obstet Gynecol. 1995 Oct;173(4):1306-9.
PMID: 7485343 [PubMed - indexed for MEDLINE]

241: Lithgow GJ, White TM, Melov S, Johnson TE.
Thermotolerance and extended life-span conferred by single-gene mutations and
induced by thermal stress.
Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7540-4.
PMID: 7638227 [PubMed - indexed for MEDLINE]

242: Melov S, Lithgow GJ, Fischer DR, Tedesco PM, Johnson TE.
Increased frequency of deletions in the mitochondrial genome with age of
Caenorhabditis elegans.
Nucleic Acids Res. 1995 Apr 25;23(8):1419-25.
PMID: 7753635 [PubMed - indexed for MEDLINE]

243: Eriksen N, Kumar SB, Fukuchi K, Martin GM, Benditt EP.
Molecular mimicry: histone H3 and mycobacterial protein epitopes.
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2150-3.
PMID: 7534413 [PubMed - indexed for MEDLINE]

244: Kellner LH, Weiss RR, Weiner Z, Neuer M, Martin GM, Schulman H, Lipper S.
The advantages of using triple-marker screening for chromosomal abnormalities.
Am J Obstet Gynecol. 1995 Mar;172(3):831-6.
PMID: 7534448 [PubMed - indexed for MEDLINE]

245: Kennedy BK, Austriaco NR Jr, Zhang J, Guarente L.
Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.
Cell. 1995 Feb 10;80(3):485-96.
PMID: 7859289 [PubMed - indexed for MEDLINE]

246: Oshima J, Campisi J, Tannock TC, Martin GM.
Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs
from that observed in senescing fibroblasts from normal donors.
J Cell Physiol. 1995 Feb;162(2):277-83.
PMID: 7822435 [PubMed - indexed for MEDLINE]

247: Kennedy BK, Austriaco NR Jr, Guarente L.
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced
life span.
J Cell Biol. 1994 Dec;127(6 Pt 2):1985-93.
PMID: 7806576 [PubMed - indexed for MEDLINE]

248: Vaupel JW, Johnson TE, Lithgow GJ.
Rates of mortality in populations of Caenorhabditis elegans.
Science. 1994 Nov 4;266(5186):826; author reply 828. No abstract available.
PMID: 7973641 [PubMed - indexed for MEDLINE]

249: Hearn MG, Edland SD, Ogburn CE, Smith AC, Bird TD, Martin GM, Fukuchi K.
Trypsin inhibitor activities of fibroblasts increase with age of donor and are
unaltered in familial Alzheimer's disease.
Exp Gerontol. 1994 Nov-Dec;29(6):611-23.
PMID: 9435914 [PubMed - indexed for MEDLINE]

250: Martin GM.
Genetic modulation of telomeric terminal restriction-fragment length: relevance
for clonal aging and late-life disease.
Am J Hum Genet. 1994 Nov;55(5):866-9. Review. No abstract available.
PMID: 7977347 [PubMed - indexed for MEDLINE]

251: Lithgow GJ, White TM, Hinerfeld DA, Johnson TE.
Thermotolerance of a long-lived mutant of Caenorhabditis elegans.
J Gerontol. 1994 Nov;49(6):B270-6.
PMID: 7963273 [PubMed - indexed for MEDLINE]

252: Sopher BL, Fukuchi K, Smith AC, Leppig KA, Furlong CE, Martin GM.
Cytotoxicity mediated by conditional expression of a carboxyl-terminal
derivative of the beta-amyloid precursor protein.
Brain Res Mol Brain Res. 1994 Oct;26(1-2):207-17.
PMID: 7854049 [PubMed - indexed for MEDLINE]

253: Skinner DM, Martin GM, Harley C, Kolb B, Pridgar A, Bechara A, van der
Kooy D.
Acquisition of conditional discriminations in hippocampal lesioned and
decorticated rats: evidence for learning that is separate from both simple
classical conditioning and configural learning.
Behav Neurosci. 1994 Oct;108(5):911-26.
PMID: 7826514 [PubMed - indexed for MEDLINE]

254: Oshima J, Yu CE, Boehnke M, Weber JL, Edelhoff S, Wagner MJ, Wells DE,
Wood S, Disteche CM, Martin GM, et al.
Integrated mapping analysis of the Werner syndrome region of chromosome 8.
Genomics. 1994 Sep 1;23(1):100-13.
PMID: 7829057 [PubMed - indexed for MEDLINE]

255: Ogburn CE, Turker MS, Kavanagh TJ, Disteche CM, Smith AC, Fukuchi K,
Martin GM.
Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator
phenotypes.
Somat Cell Mol Genet. 1994 Sep;20(5):361-70.
PMID: 7825058 [PubMed - indexed for MEDLINE]

256: Fukuchi KI, Kunkel DD, Schwartzkroin PA, Kamino K, Ogburn CE, Furlong CE,
Martin GM.
Overexpression of a C-terminal portion of the beta-amyloid precursor protein in
mouse brains by transplantation of transformed neuronal cells.
Exp Neurol. 1994 Jun;127(2):253-64.
PMID: 8033965 [PubMed - indexed for MEDLINE]

257: Fukuchi K, Hearn MG, Deeb SS, Smith AC, Dang N, Miyazaki J, Bothwell M,
Martin GM.
Activity assays of nine heterogeneous promoters in neural and other cultured
cells.
In Vitro Cell Dev Biol Anim. 1994 May;30A(5):300-5.
PMID: 8069455 [PubMed - indexed for MEDLINE]

258: Kavanagh TJ, Raghu G, White CC, Martin GM, Rabinovitch PS, Eaton DL.
Enhancement of glutathione content in glutathione synthetase-deficient
fibroblasts from a patient with 5-oxoprolinuria via metabolic cooperation with
normal fibroblasts.
Exp Cell Res. 1994 May;212(1):69-76.
PMID: 7909755 [PubMed - indexed for MEDLINE]

259: Melov S, Hertz GZ, Stormo GD, Johnson TE.
Detection of deletions in the mitochondrial genome of Caenorhabditis elegans.
Nucleic Acids Res. 1994 Mar 25;22(6):1075-8.
PMID: 8152911 [PubMed - indexed for MEDLINE]

260: Brooks A, Lithgow GJ, Johnson TE.
Mortality rates in a genetically heterogeneous population of Caenorhabditis
elegans.
Science. 1994 Feb 4;263(5147):668-71.
PMID: 8303273 [PubMed - indexed for MEDLINE]

261: Runger TM, Bauer C, Dekant B, Moller K, Sobotta P, Czerny C, Poot M,
Martin GM.
Hypermutable ligation of plasmid DNA ends in cells from patients with Werner
syndrome.
J Invest Dermatol. 1994 Jan;102(1):45-8.
PMID: 8288910 [PubMed - indexed for MEDLINE]

262: Fukuchi K, Ogburn CE, Smith AC, Kunkel DD, Furlong CE, Deeb SS, Nochlin D,
Sumi SM, Martin GM.
Transgenic animal models for Alzheimer's disease.
Ann N Y Acad Sci. 1993 Sep 24;695:217-23. Review.
PMID: 8239285 [PubMed - indexed for MEDLINE]

263: Martin GM.
Clonal attenuation: causes and consequences.
J Gerontol. 1993 Sep;48(5):B171-2. No abstract available.
PMID: 8366255 [PubMed - indexed for MEDLINE]

264: Martin GM.
FRAR course on laboratory approaches to aging. "Orphan" phenotypes in
gerontological research.
Aging (Milano). 1993 Aug;5(4):325-32. Review.
PMID: 8297936 [PubMed - indexed for MEDLINE]

265: Fukuchi K, Sopher B, Furlong CE, Smith AC, Dang N, Martin GM.
Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid
precursor protein.
Neurosci Lett. 1993 May 14;154(1-2):145-8.
PMID: 8361630 [PubMed - indexed for MEDLINE]

266: Bechara A, Martin GM, Pridgar A, van der Kooy D.
The parabrachial nucleus: a brain stem substrate critical for mediating the
aversive motivational effects of morphine.
Behav Neurosci. 1993 Feb;107(1):147-60.
PMID: 8383500 [PubMed - indexed for MEDLINE]

267: Fukuchi K, Sopher B, Martin GM.
Neurotoxicity of beta-amyloid.
Nature. 1993 Jan 14;361(6408):122-3. No abstract available.
PMID: 8421518 [PubMed - indexed for MEDLINE]

268: Bryant EM, Bird TD, Ogburn CE, Traylor GH, Lampe TH, Martin GM.
Lack of detectable radiation hypersensitivity in lymphoblastoid cells from
multiple pedigrees of familial Alzheimer disease.
Alzheimer Dis Assoc Disord. 1993 Summer;7(2):88-97.
PMID: 8347332 [PubMed - indexed for MEDLINE]

269: Wijsman EM, Bird TD, Martin GM, Schellenberg GD.
The Seattle Alzheimer's disease data set.
Genet Epidemiol. 1993;10(6):365-9. Review.
PMID: 8314028 [PubMed - indexed for MEDLINE]

270: Johnson TE, Tedesco PM, Lithgow GJ.
Comparing mutants, selective breeding, and transgenics in the dissection of
aging processes of Caenorhabditis elegans.
Genetica. 1993;91(1-3):65-77. Review.
PMID: 8125279 [PubMed - indexed for MEDLINE]

271: Martin GM.
Abiotrophic gene action in Homo sapiens: potential mechanisms and significance
for the pathobiology of aging.
Genetica. 1993;91(1-3):265-77. Review.
PMID: 8125275 [PubMed - indexed for MEDLINE]

272: Skinner DM, Martin GM.
Conditioned taste aversions support drug discrimination learning at low dosages
of morphine.
Behav Neural Biol. 1992 Nov;58(3):236-41.
PMID: 1456945 [PubMed - indexed for MEDLINE]

273: Fukuchi K, Kamino K, Deeb SS, Furlong CE, Sundstrom JA, Smith AC, Martin
GM.
Expression of a carboxy-terminal region of the beta-amyloid precursor protein
in a heterogeneous culture of neuroblastoma cells: evidence for altered
processing and selective neurotoxicity.
Brain Res Mol Brain Res. 1992 Nov;16(1-2):37-46.
PMID: 1334198 [PubMed - indexed for MEDLINE]

274: Poot M, Hoehn H, Runger TM, Martin GM.
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid
cell lines.
Exp Cell Res. 1992 Oct;202(2):267-73.
PMID: 1327851 [PubMed - indexed for MEDLINE]

275: Johnson TE, Lithgow GJ.
The search for the genetic basis of aging: the identification of gerontogenes
in the nematode Caenorhabditis elegans.
J Am Geriatr Soc. 1992 Sep;40(9):936-45. Review.
PMID: 1355097 [PubMed - indexed for MEDLINE]

276: Melov S, Vaughan H, Cotterill S.
Molecular characterisation of the gene for the 180 kDa subunit of the DNA
polymerase-primase of Drosophila melanogaster.
J Cell Sci. 1992 Aug;102 ( Pt 4):847-56.
PMID: 1429896 [PubMed - indexed for MEDLINE]

277: Martin GM.
Clonal attenuation and cell senescence: the next 30 years.
Exp Gerontol. 1992 Jul-Aug;27(4):455-9. No abstract available.
PMID: 1459222 [PubMed - indexed for MEDLINE]

278: Fukuchi K, Deeb SS, Kamino K, Ogburn CE, Snow AD, Sekiguchi RT, Wight TN,
Piussan H, Martin GM.
Increased expression of beta-amyloid protein precursor and
microtubule-associated protein tau during the differentiation of murine
embryonal carcinoma cells.
J Neurochem. 1992 May;58(5):1863-73.
PMID: 1560239 [PubMed - indexed for MEDLINE]

279: Schellenberg GD, Martin GM, Wijsman EM, Nakura J, Miki T, Ogihara T.
Homozygosity mapping and Werner's syndrome.
Lancet. 1992 Apr 18;339(8799):1002. No abstract available.
PMID: 1348795 [PubMed - indexed for MEDLINE]

280: Zitnik GD, Bingel SA, Sumi SM, Martin GM.
Survival curves, reproductive life span and age-related pathology of Mus
caroli.
Lab Anim Sci. 1992 Apr;42(2):119-26.
PMID: 1318441 [PubMed - indexed for MEDLINE]

281: Schellenberg GD, Boehnke M, Wijsman EM, Moore DK, Martin GM, Bird TD.
Genetic association and linkage analysis of the apolipoprotein CII locus and
familial Alzheimer's disease.
Ann Neurol. 1992 Feb;31(2):223-7.
PMID: 1349467 [PubMed - indexed for MEDLINE]

282: Fukuchi K, Kamino K, Deeb SS, Smith AC, Dang T, Martin GM.
Overexpression of amyloid precursor protein alters its normal processing and is
associated with neurotoxicity.
Biochem Biophys Res Commun. 1992 Jan 15;182(1):165-73.
PMID: 1731777 [PubMed - indexed for MEDLINE]

283: Turker MS, Duffin KZ, Smith AC, Martin GM, Martin AW, DiMartino DL, Kersey
DS.
Multidrug resistance phenotype associated with selection of an aminopterin
resistant dog kidney cell line.
Pharmacogenetics. 1991 Dec;1(3):149-60.
PMID: 1688246 [PubMed - indexed for MEDLINE]

284: Tissenbaum HA, Parry DJ.
The effect of partial denervation of tibialis anterior (TA) muscle on the
number and sizes of motorneurons in TA motornucleus of normal and dystrophic
(C57BL dy2j/dy2j) mice.
Can J Physiol Pharmacol. 1991 Nov;69(11):1769-73.
PMID: 1804521 [PubMed - indexed for MEDLINE]

285: Schellenberg GD, Anderson L, O'dahl S, Wisjman EM, Sadovnick AD, Ball MJ,
Larson EB, Kukull WA, Martin GM, Roses AD, et al.
APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.
Am J Hum Genet. 1991 Sep;49(3):511-7.
PMID: 1679288 [PubMed - indexed for MEDLINE]

286: Martin GM.
Genetic and environmental modulations of chromosomal stability: their roles in
aging and oncogenesis.
Ann N Y Acad Sci. 1991;621:401-17. Review.
PMID: 1859100 [PubMed - indexed for MEDLINE]

287: Kavanagh TJ, Grossmann A, Jaecks EP, Jinneman JC, Eaton DL, Martin GM,
Rabinovitch PS.
Proliferative capacity of human peripheral blood lymphocytes sorted on the
basis of glutathione content.
J Cell Physiol. 1990 Dec;145(3):472-80.
PMID: 1703168 [PubMed - indexed for MEDLINE]

288: Martin GM, Schellenberg GD, Wijsman EM, Bird TD.
Alzheimer's disease. Dominant susceptibility genes.
Nature. 1990 Sep 13;347(6289):124. No abstract available.
PMID: 2395467 [PubMed - indexed for MEDLINE]

289: Fukuchi K, Tanaka K, Kumahara Y, Marumo K, Pride MB, Martin GM, Monnat RJ
Jr.
Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in
Werner syndrome patients.
Hum Genet. 1990 Feb;84(3):249-52.
PMID: 2303247 [PubMed - indexed for MEDLINE]

290: Martin GM, Gans M, van der Kooy D.
Discriminative properties of morphine that modulate associations between tastes
and lithium chloride.
J Exp Psychol Anim Behav Process. 1990 Jan;16(1):56-68.
PMID: 2154527 [PubMed - indexed for MEDLINE]

291: Bird TD, Schellenberg GD, Wijsman EM, Martin GM.
Evidence for etiologic heterogeneity in Alzheimer's disease.
Neurobiol Aging. 1989 Sep-Oct;10(5):432-4; discussion 446-8.
PMID: 2812202 [PubMed - indexed for MEDLINE]

292: Fukuchi K, Martin GM, Monnat RJ Jr.
Mutator phenotype of Werner syndrome is characterized by extensive deletions.
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5893-7. Erratum in: Proc Natl Acad Sci
U S A 1989 Oct;86(20):7994.
PMID: 2762303 [PubMed - indexed for MEDLINE]

293: Gaber RF, Copple DM, Kennedy BK, Vidal M, Bard M.
The yeast gene ERG6 is required for normal membrane function but is not
essential for biosynthesis of the cell-cycle-sparking sterol.
Mol Cell Biol. 1989 Aug;9(8):3447-56.
PMID: 2677674 [PubMed - indexed for MEDLINE]

294: Turker MS, Swisshelm K, Smith AC, Martin GM.
A partial methylation profile for a CpG site is stably maintained in mammalian
tissues and cultured cell lines.
J Biol Chem. 1989 Jul 15;264(20):11632-6.
PMID: 2545677 [PubMed - indexed for MEDLINE]

295: Fukuchi K, Martin GM, Deeb SS.
Sequence of the protease inhibitor domain of the A4 amyloid protein precursor
of Mus domesticus.
Nucleic Acids Res. 1989 Jul 11;17(13):5396. No abstract available.
PMID: 2569710 [PubMed - indexed for MEDLINE]

296: Martin GM, Doyle DV.
A flavor paired with lithium chloride blocks the formation of a
pentobarbital-lithium chloride association.
Behav Neural Biol. 1989 Jul;52(1):108-15.
PMID: 2547355 [PubMed - indexed for MEDLINE]

297: Weingarten HP, Martin GM.
Mechanisms of conditioned meal initiation.
Physiol Behav. 1989 Apr;45(4):735-40.
PMID: 2780842 [PubMed - indexed for MEDLINE]

298: Turker MS, Stambrook PJ, Tischfield JA, Smith AC, Martin GM.
Allelic variation linked to adenine phosphoribosyltransferase locus in mouse
teratocarcinoma cell line and feral-derived mouse strains.
Somat Cell Mol Genet. 1989 Mar;15(2):159-66.
PMID: 2928841 [PubMed - indexed for MEDLINE]

299: Martin GM.
Genetic modulation of the senescent phenotype in Homo sapiens.
Genome. 1989;31(1):390-7. Review.
PMID: 2687104 [PubMed - indexed for MEDLINE]

300: Schellenberg GD, Bird TD, Wijsman EM, Moore DK, Martin GM.
The genetics of Alzheimer's disease.
Biomed Pharmacother. 1989;43(7):463-8. Review.
PMID: 2531010 [PubMed - indexed for MEDLINE]

301: Kavanagh TJ, Martin GM, Livesey JC, Rabinovitch PS.
Direct evidence of intercellular sharing of glutathione via metabolic
cooperation.
J Cell Physiol. 1988 Nov;137(2):353-9.
PMID: 3192619 [PubMed - indexed for MEDLINE]

302: Martin GM.
Building on the framework: the Academy in the 1950s.
Arch Phys Med Rehabil. 1988 Oct;69 Spec No:15-9. No abstract available.
PMID: 3056324 [PubMed - indexed for MEDLINE]

303: Martin GM.
A community hospital-based regional laboratory service. The Royal Inland
Hospital regional laboratory service.
Arch Pathol Lab Med. 1988 Sep;112(9):950-2. No abstract available.
PMID: 3415448 [PubMed - indexed for MEDLINE]

304: Martin GM, Bechara A, van der Kooy D.
Morphine preexposure attenuates the aversive properties of opiates without
preexposure to the aversive properties.
Pharmacol Biochem Behav. 1988 Jul;30(3):687-92.
PMID: 3211978 [PubMed - indexed for MEDLINE]

305: Turker MS, Monnat RJ Jr, Fukuchi K, Johnston PA, Ogburn CE, Weller RE,
Park JF, Martin GM.
A novel class of unstable 6-thioguanine-resistant cells from dog and human
kidneys.
Cell Biol Toxicol. 1988 Jun;4(2):211-23.
PMID: 3233532 [PubMed - indexed for MEDLINE]

306: Wolf NS, Giddens WE, Martin GM.
Life table analysis and pathologic observations in male mice of a long-lived
hybrid strain (Af X C57BL/6)F1.
J Gerontol. 1988 May;43(3):B71-8.
PMID: 2966191 [PubMed - indexed for MEDLINE]

307: Martin GM, Turker MS.
Model systems for the genetic analysis of mechanisms of aging.
J Gerontol. 1988 Mar;43(2):B33-9. Review. No abstract available.
PMID: 3126224 [PubMed - indexed for MEDLINE]

308: Martin GM.
Constitutional, somatic genetic and environmental aspects of the phenotypic
diversity of aging in human subjects.
Basic Life Sci. 1988;43:183-90. Review. No abstract available.
PMID: 3284519 [PubMed - indexed for MEDLINE]

309: Revusky S, Martin GM.
Glucocorticoids attenuate taste aversions produced by toxins in rats.
Psychopharmacology (Berl). 1988;96(3):400-7.
PMID: 3146775 [PubMed - indexed for MEDLINE]

310: Martin GM.
Constitutional genetic markers of aging.
Exp Gerontol. 1988;23(4-5):257-70. Review.
PMID: 3058489 [PubMed - indexed for MEDLINE]

311: Kavanagh TJ, Martin GM, el-Fouly MH, Trosko JE, Chang CC, Rabinovitch PS.
Flow cytometry and scrape-loading/dye transfer as a rapid quantitative measure
of intercellular communication in vitro.
Cancer Res. 1987 Nov 15;47(22):6046-51.
PMID: 3311360 [PubMed - indexed for MEDLINE]

312: Aizawa S, Loeb LA, Martin GM.
Aphidicolin-resistant mutator strains of mouse teratocarcinoma.
Mol Gen Genet. 1987 Jun;208(1-2):342-8.
PMID: 3112523 [PubMed - indexed for MEDLINE]

313: Schellenberg GD, Deeb SS, Boehnke M, Bryant EM, Martin GM, Lampe TH, Bird
TD.
Association of an apolipoprotein CII allele with familial dementia of the
Alzheimer type.
J Neurogenet. 1987 Apr;4(2-3):97-108.
PMID: 2885403 [PubMed - indexed for MEDLINE]

314: Martin GM.
Interactions of aging and environmental agents: the gerontological perspective.
Prog Clin Biol Res. 1987;228:25-80. Review.
PMID: 3554264 [PubMed - indexed for MEDLINE]

315: Zitnik GD, Martin GM.
Murine "housekeeping" enzyme (genetic locus: Idh-1) is regulated in an
allele-specific manner.
Dev Genet. 1987;8(3):135-50.
PMID: 3502970 [PubMed - indexed for MEDLINE]

316: Starr J, Sela S, Disteche CM, Rabinovitch PS, Ogburn CE, Smith AC, Martin
GM.
Resistance to paraquat in a mammalian cell line.
Somat Cell Mol Genet. 1986 Mar;12(2):141-52.
PMID: 3457475 [PubMed - indexed for MEDLINE]

317: Turker MS, Tischfield JA, Rabinovitch P, Stambrook PJ, Trill JJ, Smith AC,
Ogburn CE, Martin GM.
Differentiation alters the unstable expression of adenine
phosphoribosyltransferase in mouse teratocarcinoma cells.
J Exp Pathol. 1986 Summer;2(4):299-311.
PMID: 3783283 [PubMed - indexed for MEDLINE]

318: Turker MS, Martin GM.
Induction of adenine salvage in mouse cell lines deficient in adenine
phosphoribosyltransferase.
Mol Cell Biol. 1985 Oct;5(10):2662-8.
PMID: 3837181 [PubMed - indexed for MEDLINE]

319: Subba Rao K, Martin GM, Loeb LA.
Fidelity of DNA polymerase-beta in neurons from young and very aged mice.
J Neurochem. 1985 Oct;45(4):1273-8.
PMID: 3161998 [PubMed - indexed for MEDLINE]

320: Aizawa S, Ohashi M, Loeb LA, Martin GM.
Multipotent mutator strain of mouse teratocarcinoma cells.
Somat Cell Mol Genet. 1985 May;11(3):211-6.
PMID: 3859019 [PubMed - indexed for MEDLINE]

321: Martin GM, Lett BT.
Formation of associations of colored and flavored food with induced sickness in
five avian species.
Behav Neural Biol. 1985 May;43(3):223-37.
PMID: 3842247 [PubMed - indexed for MEDLINE]

322: Martin GM, Smith AC, Ketterer DJ, Ogburn CE, Disteche CM.
Increased chromosomal aberrations in first metaphases of cells isolated from
the kidneys of aged mice.
Isr J Med Sci. 1985 Mar;21(3):296-301.
PMID: 3997491 [PubMed - indexed for MEDLINE]

323: Turker MS, Ogburn CE, Martin GM.
Subpopulations of fibroblasts from mouse skeletal muscle defined by clonal
variation for 5' nucleotidase expression.
J Cell Physiol. 1985 Feb;122(2):171-7.
PMID: 2578472 [PubMed - indexed for MEDLINE]

324: Silber JR, Fry M, Martin GM, Loeb LA.
Fidelity of DNA polymerases isolated from regenerating liver chromatin of aging
Mus musculus.
J Biol Chem. 1985 Jan 25;260(2):1304-10.
PMID: 3968062 [PubMed - indexed for MEDLINE]

325: Salk D, Au K, Hoehn H, Martin GM.
Cytogenetic aspects of Werner syndrome.
Adv Exp Med Biol. 1985;190:541-6. No abstract available.
PMID: 4083162 [PubMed - indexed for MEDLINE]

326: Salk D, Bryant E, Hoehn H, Johnston P, Martin GM.
Growth characteristics of Werner syndrome cells in vitro.
Adv Exp Med Biol. 1985;190:305-11. No abstract available.
PMID: 4083155 [PubMed - indexed for MEDLINE]

327: Kennedy BK, Friedmann N.
Terconazole cream and suppositories: plasma terconazole following vaginal
administration.
Gynakol Rundsch. 1985;25 Suppl 1:26-32. No abstract available.
PMID: 4007621 [PubMed - indexed for MEDLINE]

328: Martin GM.
Genetics and aging; the Werner syndrome as a segmental progeroid syndrome.
Adv Exp Med Biol. 1985;190:161-70. Review.
PMID: 3909765 [PubMed - indexed for MEDLINE]

329: Horn PL, Turker MS, Ogburn CE, Disteche CM, Martin GM.
A cloning assay for 6-thioguanine resistance provides evidence against certain
somatic mutational theories of aging.
J Cell Physiol. 1984 Nov;121(2):309-15.
PMID: 6490730 [PubMed - indexed for MEDLINE]

330: Fry M, Silber J, Loeb LA, Martin GM.
Delayed and reduced cell replication and diminishing levels of DNA
polymerase-alpha in regenerating liver of aging mice.
J Cell Physiol. 1984 Mar;118(3):225-32.
PMID: 6699097 [PubMed - indexed for MEDLINE]

331: Martin GM, Ogburn CE, Au K, Disteche CM.
Altered differentiation, indefinite growth potential, diminished
tumorigenicity, and suppressed chimerization potential of hybrids between mouse
teratocarcinoma cells and thymocytes.
J Exp Pathol. 1984;1(2):103-33.
PMID: 6599936 [PubMed - indexed for MEDLINE]

332: Turker MS, Smith AC, Martin GM.
High frequency "switching" at the adenine phosphoribosyltransferase locus in
multipotent mouse teratocarcinoma stem cells.
Somat Cell Mol Genet. 1984 Jan;10(1):55-69.
PMID: 6583853 [PubMed - indexed for MEDLINE]

333: Martin GM.
Medical technology of the 1980's: giving birth to new health careers.
OCCUP Outlook Q. 1983 Winter;27(4):3-14. No abstract available.
PMID: 10310370 [PubMed - indexed for MEDLINE]

334: Martin GM.
Effect of pairings of pentobarbital with lithium chloride on the capacity of
pentobarbital to maintain a conditioned aversion.
Behav Neural Biol. 1983 Sep;39(1):145-8.
PMID: 6318717 [PubMed - indexed for MEDLINE]

335: Aizawa S, Loeb LA, Martin GM.
Mouse teratocarcinoma cells resistant to aphidicolin and arabinofuranosyl
cytosine: isolation and initial characterization.
J Cell Physiol. 1983 Apr;115(1):9-14.
PMID: 6403560 [PubMed - indexed for MEDLINE]

336: Kim S, Turker MS, Chi EY, Sela S, Martin GM.
Preparation of multivesicular liposomes.
Biochim Biophys Acta. 1983 Mar 9;728(3):339-48.
PMID: 6824663 [PubMed - indexed for MEDLINE]

337: Martin GM.
Industrial robots join the work force.
OCCUP Outlook Q. 1982 Fall;26(3):2-11. No abstract available.
PMID: 10317334 [PubMed - indexed for MEDLINE]

338: Liu PK, Chang CC, Trosko JE, Dube DK, Martin GM, Loeb LA.
Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.
Proc Natl Acad Sci U S A. 1983 Feb;80(3):797-801.
PMID: 6402775 [PubMed - indexed for MEDLINE]

339: Martin GM, Ogburn CE, Wight TN.
Comparative rates of decline in the primary cloning efficiencies of smooth
muscle cells from the aging thoracic aorta of two murine species of contrasting
maximum life span potentials.
Am J Pathol. 1983 Feb;110(2):236-45.
PMID: 6401930 [PubMed - indexed for MEDLINE]

340: Bryant EM, Martin GM, Hoehn H.
Fragile X expression studied by clonal analysis and somatic cell hybridization.
Cytogenet Cell Genet. 1983;35(3):223-5.
PMID: 6683146 [PubMed - indexed for MEDLINE]

341: Pendergrass WR, Saulewicz AC, Burmer GC, Rabinovitch PS, Norwood TH,
Martin GM.
Evidence that a critical threshold of DNA polymerase-alpha activity may be
required for the initiation of DNA synthesis in mammalian cell heterokaryons.
J Cell Physiol. 1982 Oct;113(1):141-51.
PMID: 7130287 [PubMed - indexed for MEDLINE]

342: Rabinovitch PS, Martin GM.
Encephalomyocarditis virus as a probe of errors in macromolecular synthesis in
aging mice.
Mech Ageing Dev. 1982 Oct;20(2):155-63.
PMID: 6294419 [PubMed - indexed for MEDLINE]

343: Johnston P, Salk D, Martin GM, Hoehn H.
Cultivated cells from mid-trimester amniotic fluids: IV. Cell type
indentification via one and two-dimensional electrophoresis of clonal whole cell
homogenates.
Prenat Diagn. 1982 Apr;2(2):79-88.
PMID: 7145843 [PubMed - indexed for MEDLINE]

344: Rabinovitch PS, Martin GM, Hoehn H.
Interphase flow-cytogenetics: correlation of DNA fluorescence to aneuploidy in
human fibroblast cultures.
Hum Genet. 1982;61(3):246-9.
PMID: 7173867 [PubMed - indexed for MEDLINE]

345: Martin GM, Kirkwood T, Fry M, Goldstein S, Brown WT, Salk D.
Workshop on aging and genetics.
Prog Clin Biol Res. 1982;103 Pt A:339-42. No abstract available.
PMID: 6219399 [PubMed - indexed for MEDLINE]

346: Martin GM.
Syndromes of accelerated aging.
Natl Cancer Inst Monogr. 1982;60:241-7. Review.
PMID: 6214719 [PubMed - indexed for MEDLINE]

347: Martinez AO, Norwood TH, Martin GM.
Growth inhibition and morphologic modulation of human fibroblastlike cells by
erythromycin.
In Vitro. 1981 Nov;17(11):979-84.
PMID: 7319530 [PubMed - indexed for MEDLINE]

348: Kim S, Martin GM.
Preparation of cell-size unilamellar liposomes with high captured volume and
defined size distribution.
Biochim Biophys Acta. 1981 Aug 6;646(1):1-9.
PMID: 7272296 [PubMed - indexed for MEDLINE]

349: Fry M, Loeb LA, Martin GM.
On the activity and fidelity of chromatin-associated hepatic DNA
polymerase-beta in aging murine species of different life spans.
J Cell Physiol. 1981 Mar;106(3):435-44.
PMID: 7217221 [PubMed - indexed for MEDLINE]

350: Salk D, Bryant E, Au K, Hoehn H, Martin GM.
Systematic growth studies, cocultivation, and cell hybridization studies of
Werner syndrome cultured skin fibroblasts.
Hum Genet. 1981;58(3):310-6.
PMID: 7327553 [PubMed - indexed for MEDLINE]

351: Salk D, Au K, Hoehn H, Martin GM.
Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated
translocation mosaicism.
Cytogenet Cell Genet. 1981;30(2):92-107.
PMID: 7273860 [PubMed - indexed for MEDLINE]

352: Salk D, Au K, Hoehn H, Stenchever MR, Martin GM.
Evidence of clonal attenuation, clonal succession, and clonal expansion in mass
cultures of aging Werner's syndrome skin fibroblasts.
Cytogenet Cell Genet. 1981;30(2):108-17.
PMID: 7273855 [PubMed - indexed for MEDLINE]

353: Salk D, Au K, Hoehn H, Martin GM.
Effects of radical-scavenging enzymes and reduced oxygen exposure on growth and
chromosome abnormalities of Werner syndrome cultured skin fibroblasts.
Hum Genet. 1981;57(3):269-75.
PMID: 7250969 [PubMed - indexed for MEDLINE]

354: Fry M, Shearman CW, Martin GM, Loeb LA.
On the fidelity of deoxyribonucleic acid synthesis directed by
chromatin-associated deoxyribonucleic acid polymerase beta.
Biochemistry. 1980 Dec 9;19(25):5939-46.
PMID: 6257296 [PubMed - indexed for MEDLINE]

355: Martin GM, Gullickson G Jr, Gerken C.
Graduate medical education and certification in physical medicine and
rehabilitation.
Arch Phys Med Rehabil. 1980 Jul;61(7):291-7.
PMID: 7396680 [PubMed - indexed for MEDLINE]

356: Gillette K, Martin GM, Bellingham WP.
Differential use of food and water cues in the formation of conditioned
aversions by domestic chicks (Gallus gallus).
J Exp Psychol Anim Behav Process. 1980 Apr;6(2):99-111.
PMID: 7373233 [PubMed - indexed for MEDLINE]

357: Hoehn H, Simpson M, Bryant EM, Rabinovitch PS, Salk D, Martin GM.
Effects of chromosome constitution on growth and longevity of human skin
fibroblast cultures.
Am J Med Genet. 1980;7(2):141-54.
PMID: 7468645 [PubMed - indexed for MEDLINE]

358: Martin GM, Hoehn H, Bryant EM.
Evidence against somatic mutation as a mechanism of clonal senescence.
Adv Exp Med Biol. 1980;129:139-45. No abstract available.
PMID: 7395628 [PubMed - indexed for MEDLINE]

359: Martin GM.
Genotropic theories of aging: an overview.
Adv Pathobiol. 1980;7:5-20. Review.
PMID: 6996462 [PubMed - indexed for MEDLINE]

360: Storlien LH, Martin GM, Bellingham WP.
Body weight regulation over the estrous cycle of the rat: basal insulin levels
and effect of vagotomy.
Behav Neural Biol. 1979 Sep;27(1):87-95. No abstract available.
PMID: 574004 [PubMed - indexed for MEDLINE]

361: Norwood TH, Hoehn H, Salk D, Martin GM.
Cellular aging in Werner's syndrome: a unique phenotype?
J Invest Dermatol. 1979 Jul;73(1):92-6.
PMID: 448183 [PubMed - indexed for MEDLINE]

362: Lubiniecki AS, Blattner WA, Martin GM, Fialkow PJ, Dosik H, Eatherly C,
Fraumeni JF Jr.
SV40 T-antigen expression in cultured fibroblasts from patients with Down
syndrome and their parents.
Am J Hum Genet. 1979 Jul;31(4):469-77. No abstract available.
PMID: 225951 [PubMed - indexed for MEDLINE]

363: Bryant EM, Hoehn H, Martin GM.
Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by
euploid cell hybridisation.
Nature. 1979 Jun 28;279(5716):795-6. No abstract available.
PMID: 450130 [PubMed - indexed for MEDLINE]

364: Martin GM.
Genetic and evolutionary aspects of aging.
Fed Proc. 1979 May;38(6):1962-7. Review.
PMID: 155534 [PubMed - indexed for MEDLINE]

365: Martin GM, Nestel P.
Changes in cholesterol metabolism with dietary cholesterol in children with
familial hypercholesterolaemia.
Clin Sci (Lond). 1979 Apr;56(4):377-80.
PMID: 477222 [PubMed - indexed for MEDLINE]

366: Norwood TH, Pendergrass W, Bornstein P, Martin GM.
DNA synthesis of sublethally injured cells in heterokaryons and its relevance
to clonal senescence.
Exp Cell Res. 1979 Mar 1;119(1):15-21. No abstract available.
PMID: 761601 [PubMed - indexed for MEDLINE]

367: Martin GM.
Proliferative homeostasis and its age-related aberrations.
Mech Ageing Dev. 1979 Mar;9(5-6):385-91. No abstract available.
PMID: 459570 [PubMed - indexed for MEDLINE]

368: Bolas KC, Bellingham WP, Martin GM.
Aversive properties of cycloheximide versus memory inhibition in chickens'
formation of visually cued food aversions.
Pharmacol Biochem Behav. 1979 Feb;10(2):251-4.
PMID: 450935 [PubMed - indexed for MEDLINE]

369: Martin GM, Bellingham WP.
Learning of visual food aversions by chickens (Gallus gallus) over long delays.
Behav Neural Biol. 1979 Jan;25(1):58-78. No abstract available.
PMID: 454340 [PubMed - indexed for MEDLINE]

370: Martinez AO, Norwood TH, Prothero JW, Martin GM.
Evidence for clonal attenuation of growth potential in HeLa cells.
In Vitro. 1978 Dec;14(12):996-1002.
PMID: 738739 [PubMed - indexed for MEDLINE]

371: Bryant EM, Crouch E, Bornstein P, Martin GM, Johnston P, Hoehn H.
Regulation of growth and gene activity in euploid hybrids between human
neonatal fibroblasts and epithelioid amniotic fluid cells.
Am J Hum Genet. 1978 Jul;30(4):392-405.
PMID: 717401 [PubMed - indexed for MEDLINE]

372: Hoehn H, Bryant EM, Martin GM.
The replicative life spans of euploid hybrids derived from short-lived and
long-lived human skin fibroblast cultures.
Cytogenet Cell Genet. 1978;21(5):282-95.
PMID: 679728 [PubMed - indexed for MEDLINE]

373: Martin GM.
Genetic syndromes in man with potential relevance to the pathobiology of aging.
Birth Defects Orig Artic Ser. 1978;14(1):5-39. Review. No abstract available.
PMID: 147113 [PubMed - indexed for MEDLINE]

374: Martin GM.
Cellular aging--postreplicative cells. A review (Part II).
Am J Pathol. 1977 Nov;89(2):513-30. Review. No abstract available.
PMID: 335896 [PubMed - indexed for MEDLINE]

375: Martin GM.
Cellular aging--clonal senescence. A review (Part I).
Am J Pathol. 1977 Nov;89(2):484-511. Review. No abstract available.
PMID: 335895 [PubMed - indexed for MEDLINE]

376: Martin GM.
Presentation of the Rous-Whipple Award to Richmond T. Prehn, MD.
Am J Pathol. 1977 Jul;88(1):2-4. No abstract available.
PMID: 327822 [PubMed - indexed for MEDLINE]

377: Anderson RE, Benson ES, Korn D, Martin GM, Robbins SL, Scarpelli DG,
Scully RE, Thurlebeck WM, Wagner BM, Zacks SI.
Carcinogenesis testing and the pathologist.
Hum Pathol. 1977 May;8(3):353-4. No abstract available.
PMID: 852870 [PubMed - indexed for MEDLINE]

378: Ruvalcaba RH, Churesigaew S, Myhre SA, Kelley VC, Martin GM.
Children who age rapidly--progeroid syndromes: case report of a new variant.
Clin Pediatr (Phila). 1977 Mar;16(3):248-52.
PMID: 837628 [PubMed - indexed for MEDLINE]

379: Hoehn H, Au K, Karp LE, Martin GM.
Somatic stability of variant C-band heterochromatin.
Hum Genet. 1977 Feb 11;35(2):163-8.
PMID: 844861 [PubMed - indexed for MEDLINE]

380: Norwood TH, Zeigler CJ, Martin GM.
Dimethyl sulfoxide enhances polyethylene glycol-mediated somatic cell fusion.
Somatic Cell Genet. 1976 May;2(3):263-70.
PMID: 1028173 [PubMed - indexed for MEDLINE]

381: Pendergrass WR, Martin GM, Bornstein P.
Evidence contrary to the protein error hypothesis for in vitro senescence.
J Cell Physiol. 1976 Jan;87(1):3-13.
PMID: 1245556 [PubMed - indexed for MEDLINE]

382: Hoehn H, Bryant EM, Johnston P, Norwood TH, Martin GM.
Non-selective isolation, stability and longevity of hybrids between normal
human somatic cells.
Nature. 1975 Dec 18;258(5536):608-10. No abstract available.
PMID: 1207734 [PubMed - indexed for MEDLINE]

383: Storlien LH, Bellingham WP, Martin GM.
Localization of CNS glucoregulatory insulin receptors within the ventromedial
hypothalamus.
Brain Res. 1975 Oct 10;96(1):156-60. No abstract available.
PMID: 169959 [PubMed - indexed for MEDLINE]

384: Hoehn H, Bryant EM, Fantel AG, Martin GM.
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies.
III. The fetal urine as a potential source of clonable cells.
Humangenetik. 1975 Oct 7;29(4):285-90.
PMID: 1176144 [PubMed - indexed for MEDLINE]

385: Norwood TH, Pendergrass WR, Martin GM.
Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with
cells of unlimited growth potential.
J Cell Biol. 1975 Mar;64(3):551-6.
PMID: 1150745 [PubMed - indexed for MEDLINE]

386: Hoehn H, Bryant EM, Au K, Norwood TH, Boman H, Martin GM.
Variegated translocation mosaicism in human skin fibroblast cultures.
Cytogenet Cell Genet. 1975;15(5):282-98.
PMID: 1222585 [PubMed - indexed for MEDLINE]

387: Hoehn H, Bryant EM, Karp LE, Martin GM.
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies.
II. Cytogenetic parameters as functions of clonal type and preparative
technique.
Clin Genet. 1975 Jan;7(1):29-36.
PMID: 1167818 [PubMed - indexed for MEDLINE]

388: Martin GM, Sprague CA, Norwood TH, Pendergrass WR, Bornstein P, Hoehn H,
Arend WP.
Do hyperplastoid cell lines "differentiate themselves to death"?
Adv Exp Med Biol. 1975;53:67-90. No abstract available.
PMID: 164106 [PubMed - indexed for MEDLINE]

389: Hoehn H, Bryant EM, Karp LE, Martin GM.
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies.
I. Clonal morphology and growth potential.
Pediatr Res. 1974 Aug;8(8):746-54. No abstract available.
PMID: 4844525 [PubMed - indexed for MEDLINE]

390: Martin GM, Hoehn H.
Genetics and human disease.
Hum Pathol. 1974 Jul;5(4):387-405. Review. No abstract available.
PMID: 4600308 [PubMed - indexed for MEDLINE]

391: Norwood TH, Pendergrass WR, Sprague CA, Martin GM.
Dominance of the senescent phenotype in heterokaryons between replicative and
post-replicative human fibroblast-like cells.
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2231-5. No abstract available.
PMID: 4366757 [PubMed - indexed for MEDLINE]

392: Boffey GC, Martin GM.
A new solvent system for the thin-layer chromatographic separation of the
Dansyl derivatives of some biogenic amines.
J Chromatogr. 1974 Mar 13;90(1):178-80. No abstract available.
PMID: 4824656 [PubMed - indexed for MEDLINE]

393: Sprague CA, Hoehn H, Martin GM.
Ploidy of living clones of human somatic cells determined by mensuration at
metaphase.
J Cell Biol. 1974 Mar;60(3):781-4. No abstract available.
PMID: 4596170 [PubMed - indexed for MEDLINE]

394: Martin GM, Sprague CA, Norwood TH, Pendergrass WR.
Clonal selection, attenuation and differentiation in an in vitro model of
hyperplasia.
Am J Pathol. 1974 Jan;74(1):137-54. No abstract available.
PMID: 4809311 [PubMed - indexed for MEDLINE]

395: Purnell DM, Martin GM.
A morphologic mutation in Aspergillus nidulans associated with increased
virulence for mice.
Mycopathol Mycol Appl. 1973 Sep 28;51(1):75-9. No abstract available.
PMID: 4584520 [PubMed - indexed for MEDLINE]

396: Hoehn H, Martin GM.
Clonal variants of constitutive heterochromatin of human fibroblasts after
recovery from mitomycin treatment.
Chromosoma. 1973 Aug 10;43(2):203-10. No abstract available.
PMID: 4746718 [PubMed - indexed for MEDLINE]

397: Martin GM, Caskey PE.
Electric bed jack for hiatal hernia.
Mayo Clin Proc. 1973 Jul;48(7):501-2. No abstract available.
PMID: 4716220 [PubMed - indexed for MEDLINE]

398: Fialkow PJ, Martin GM, Sprague CA.
Replicative life-span of cultured skin fibroblasts from young mothers of
subjects with Down's syndrome: failure to detect accelerated ageing.
Am J Hum Genet. 1973 May;25(3):317-22. No abstract available.
PMID: 4268382 [PubMed - indexed for MEDLINE]

399: Fialkow PJ, Martin GM, Sprague CA.
Replicative life-span of cultured skin fibroblasts from young mothers of
subjects with Down's syndrome: failure to detect accelerated ageing.
Am J Hum Genet. 1973 May;25(3):317-22. No abstract available.
PMID: 4267468 [PubMed - indexed for MEDLINE]

400: Purnell DM, Martin GM.
Heterozygous diploid strains of Aspergillus nidulans: enhanced virulence for
mice in comparison to a prototrophic haploid strain.
Mycopathol Mycol Appl. 1973 Apr 30;49(4):307-19. No abstract available.
PMID: 4575394 [PubMed - indexed for MEDLINE]

401: Martin GM, Sprague CA.
Symposium on in vitro studies related to atherogenesis. Life histories of
hyperplastoid cell lines from aorta and skin.
Exp Mol Pathol. 1973 Apr;18(2):125-41. No abstract available.
PMID: 4634042 [PubMed - indexed for MEDLINE]

402: Hoehn H, Martin GM.
Nonrandom arrangement of human chromatin: topography of disomic markers X, Y,
and 1h plus 1.
Cytogenet Cell Genet. 1973;12(6):443-52. No abstract available.
PMID: 4791997 [PubMed - indexed for MEDLINE]

403: Hoehn H, Sprague CA, Martin GM.
Effects of cytochalasin B on cultivated human diploid fibroblasts and its use
for the isolation of tetraploid clones.
Exp Cell Res. 1973 Jan;76(1):170-4. No abstract available.
PMID: 4566311 [PubMed - indexed for MEDLINE]

404: Martin GM, Sprague CA.
Clonal senescence and atherosclerosis.
Lancet. 1972 Dec 23;2(7791):1370-1. No abstract available.
PMID: 4118240 [PubMed - indexed for MEDLINE]

405: Hoehn H, Martin GM.
Heritable alteration of human constitutive heterochromatin induced by mitomycin
C.
Exp Cell Res. 1972 Nov;75(1):275-8. No abstract available.
PMID: 4119304 [PubMed - indexed for MEDLINE]

406: Fialkow PJ, Martin GM, Klein G, Clifford P, Singh S.
Evidence for a clonal origin of head and neck tumors.
Int J Cancer. 1972 Jan 15;9(1):133-42. No abstract available.
PMID: 5015662 [PubMed - indexed for MEDLINE]

407: Amrein L, Garrett TR, Martin GM.
Use of low-voltage electrotherapy and electromyography in physical therapy.
Phys Ther. 1971 Dec;51(12):1283-7. No abstract available.
PMID: 4330230 [PubMed - indexed for MEDLINE]

408: Schutt AH, Martin GM.
Rehabilitation medicine for the patient with arthritis.
Orthop Clin North Am. 1971 Nov;2(3):623-8. No abstract available.
PMID: 5127580 [PubMed - indexed for MEDLINE]

409: Chapman JC, Martin GM.
Immunofluorescent staining of rat gastric parietal cells.
J Clin Pathol. 1971 Oct;24(7):675. No abstract available.
PMID: 4940808 [PubMed - indexed for MEDLINE]

410: Martin GM, Schwartz BR, Derr MA.
Laboratory safety and human cell-lines.
Lancet. 1971 Mar 27;1(7700):450-1. No abstract available.
PMID: 4101225 [PubMed - indexed for MEDLINE]

411: Purnell DM, Martin GM.
Aspergillus nidulans: association of certain alkaline phosphatase mutations
with decreased virulence for mice.
J Infect Dis. 1971 Mar;123(3):305-6. No abstract available.
PMID: 5111886 [PubMed - indexed for MEDLINE]

412: Martin GM.
Brief proposal on immortality: an interim solution.
Perspect Biol Med. 1971 Winter;14(2):339. No abstract available.
PMID: 5546258 [PubMed - indexed for MEDLINE]

413: Martin GM, Sprague CA.
Vinblastine induces multipolar mitoses in tetraploid human cells.
Exp Cell Res. 1970 Dec;63(2):466-7. No abstract available.
PMID: 5490346 [PubMed - indexed for MEDLINE]

414: Martin GM, Schwartz BR, Derr MA.
Human lymphoid cell lines: potential hazards to laboratory workers.
Lancet. 1970 Oct 10;2(7676):772. No abstract available.
PMID: 4195992 [PubMed - indexed for MEDLINE]

415: Martin GM, Sprague CA, Epstein CJ.
Replicative life-span of cultivated human cells. Effects of donor's age,
tissue, and genotype.
Lab Invest. 1970 Jul;23(1):86-92. No abstract available.
PMID: 5431223 [PubMed - indexed for MEDLINE]

416: Sprague CA, Kohnen PW, Martin GM.
Sirenomelia. Chromosomal breaks and abnormal associations in cultures from the
fused lower limb.
Arch Pathol. 1970 Jul;90(1):29-30. No abstract available.
PMID: 5426273 [PubMed - indexed for MEDLINE]

417: Pak TJ, Martin GM, Magness JL, Kavanaugh GJ.
Reflex sympathetic dystrophy. Review of 140 cases.
Minn Med. 1970 May;53(5):507-12. No abstract available.
PMID: 4192601 [PubMed - indexed for MEDLINE]

418: Martin GM.
Nutrition and cancer.
Lancet. 1969 Nov 8;2(7628):1014. No abstract available.
PMID: 4186968 [PubMed - indexed for MEDLINE]

419: Martin GM, Sprague CA.
Parasexual cycle in cultivated human somatic cells.
Science. 1969 Nov 7;166(906):761-3. No abstract available.
PMID: 5823317 [PubMed - indexed for MEDLINE]

420: Martin GM, Derr MA, Sprague CA.
Alkaline phosphatase constitutivity: a marker for the estimation of somatic
cell "mutation" in man.
Ann N Y Acad Sci. 1969 Oct 14;166(2):433-46. No abstract available.
PMID: 5265236 [PubMed - indexed for MEDLINE]

421: Sawtell RR, Martin GM.
Perceptual problems of the hemiplegic patient.
J Lancet. 1967 Jun;87(6):193-6. No abstract available.
PMID: 6045694 [PubMed - indexed for MEDLINE]

422: Schutt AH, Pool TL, Martin GM.
Problems of the bladder and bowel in patients with myelopathies.
J Lancet. 1967 Jun;87(6):187-92. No abstract available.
PMID: 6045693 [PubMed - indexed for MEDLINE]

423: Martin GM, Sprague C, Bryant JS.
Mitotic nondisjunction in cultivated human cells.
Nature. 1967 May 6;214(88):612-3. No abstract available.
PMID: 4226946 [PubMed - indexed for MEDLINE]

424: Martin GM.
Practical rehabilitation.
J Lancet. 1967 Apr;87(4):112-7 passim. No abstract available.
PMID: 6043885 [PubMed - indexed for MEDLINE]

425: Todaro GJ, Martin GM.
Increased susceptibility of Down's syndrome fibroblasts to transformation by
SV40.
Proc Soc Exp Biol Med. 1967 Apr;124(4):1232-6. No abstract available.
PMID: 4290464 [PubMed - indexed for MEDLINE]

426: Dorn GL, Martin GM, Purnell DM.
Genetic and cytoplasmic control of undifferentiated growth in Aspergillus
nidulans.
Life Sci. 1967 Mar 15;6(6):629-33. No abstract available.
PMID: 6034180 [PubMed - indexed for MEDLINE]

427: Papayannopoulou TG, Martin GM.
Alkaline phosphatase "constitutive" clones: evidence for de-novo heterogeneity
of established human skin fibroblast strains.
Exp Cell Res. 1967 Jan;45(1):72-84. No abstract available.
PMID: 6022324 [PubMed - indexed for MEDLINE]

428: Loder RM, Martin GM.
Establishment of human skin fibroblast cultures with an automatic wedge biopsy
instrument.
J Invest Dermatol. 1966 Dec;47(6):603-5. No abstract available.
PMID: 5957931 [PubMed - indexed for MEDLINE]

429: Martin GM.
Clonal variation of derepressed phosphatase in chromosomally mosaic cell
cultures from a child with Down's syndrome.
Exp Cell Res. 1966 Nov-Dec;44(2):341-50. No abstract available.
PMID: 4225794 [PubMed - indexed for MEDLINE]

430: Platter H, Martin GM.
Tryptophane transport in cultures of human fibroblasts.
Proc Soc Exp Biol Med. 1966 Oct;123(1):140-3. No abstract available.
PMID: 5924412 [PubMed - indexed for MEDLINE]

431: Martin GM, Tuan A.
A definitive cloning technique for human fibroblast cultures.
Proc Soc Exp Biol Med. 1966 Oct;123(1):138-40. No abstract available.
PMID: 5924411 [PubMed - indexed for MEDLINE]

432: Martin GM.
Hazards of inactivity.
JAMA. 1966 Jun 6;196(10):909-10. No abstract available.
PMID: 5952452 [PubMed - indexed for MEDLINE]

433: Epstein CJ, Martin GM, Schultz AL, Motulsky AG.
Werner's syndrome a review of its symptomatology, natural history, pathologic
features, genetics and relationship to the natural aging process.
Medicine (Baltimore). 1966 May;45(3):177-221. Review. No abstract available.
PMID: 5327241 [PubMed - indexed for MEDLINE]

434: Martin GM, Sprague C, Dunham WB.
Chromosomal analysis of "leukocyte" cell lines.
Lab Invest. 1966 Apr;15(4):692-9. No abstract available.
PMID: 5934519 [PubMed - indexed for MEDLINE]

435: Martin GM.
Accessory device for crutches.
Arch Phys Med Rehabil. 1965 Oct;46(10):715. No abstract available.
PMID: 5838055 [PubMed - indexed for MEDLINE]

436: Martin GM.
Stroke rehabilitation.
S D J Med. 1965 Sep;18(9):20-6. No abstract available.
PMID: 5213072 [PubMed - indexed for MEDLINE]

437: Epstein CJ, Martin GM, Motulsky AG.
Werner's syndrome; caricature of aging. A genetic model for the study of
degenerative diseases.
Trans Assoc Am Physicians. 1965;78:73-81. No abstract available.
PMID: 5864984 [PubMed - indexed for MEDLINE]

438: MARTIN GM.
ALKALINE PHOSPHATASE OF HUMAN SKIN FIBROBLAST CULTURES. II. KINETICS OF VARIOUS
"INDUCTIONS".
Exp Mol Pathol. 1964 Dec;90:634-47. No abstract available.
PMID: 14243139 [PubMed - OLDMEDLINE for Pre1966]

439: MARTIN GM.
ALKALINE PHOSPHATASE OF HUMAN SKIN FIBROBLAST CULTURES. I. A MICROASSAY
DEMONSTRATING STRAIN VARIATION.
Exp Mol Pathol. 1964 Dec;90:622-33. No abstract available.
PMID: 14243138 [PubMed - OLDMEDLINE for Pre1966]

440: MARTIN GM.
VARIATION OF ALKALINE PHOSPHATASE ACTIVITY AMONG CELLS OF INDUCIBLE AND
CONSTITUTIVE STRAINS OF HUMAN FIBROBLASTS.
Proc Soc Exp Biol Med. 1964 Jun;116:490-3. No abstract available.
PMID: 14193382 [PubMed - OLDMEDLINE for Pre1966]

441: MARTIN GM.
COPPER CONTENT OF HAIR AND NAILS OF NORMAL INDIVIDUALS AND OF PATIENTS WITH
HEPATOLENTICULAR DEGENERATION.
Nature. 1964 May 30;202:903-4. No abstract available.
PMID: 14190087 [PubMed - OLDMEDLINE for Pre1966]

442: MARTIN GM.
USE OF TRIS(HYDROXYMETHYL)AMINOMETHANE BUFFERS IN CULTURES OF DIPLOID HUMAN
FIBROBLASTS.
Proc Soc Exp Biol Med. 1964 May;116:167-71. No abstract available.
PMID: 14200095 [PubMed - OLDMEDLINE for Pre1966]

443: MARTIN GM.
CULTURE OF REPLICATE MONOLAYERS OF FIBROBLASTS UNDER IDENTICAL CONDITIONS.
Nature. 1964 Mar 28;201:1338-40. No abstract available.
PMID: 14151432 [PubMed - OLDMEDLINE for Pre1966]

444: MARTIN GM, DERR MA, BENDITT EP.
CERULOPLASMINS OF SEVERAL ANIMAL SPECIES. COMPARISON OF ELECTROPHORETIC
MOBILITIES AND SUBSTRATE SPECIFICITY.
Lab Invest. 1964 Mar;13:282-7. No abstract available.
PMID: 14127032 [PubMed - OLDMEDLINE for Pre1966]

445: AFONSO JF, MARTIN GM, NISCO FS, DE ALVAREZ RR.
Melanogenic ovarian tumors.
Am J Obstet Gynecol. 1962 Sep 1;84:667-76. No abstract available.
PMID: 13859538 [PubMed - OLDMEDLINE for Pre1966]

446: CALLAHAN JA, LOGAN GB, BIANCO AJ Jr, MARTIN GM, MAHER FT.
Posttraumatic acute renal failure: report of a case with unusual complications.
Mayo Clin Proc. 1962 Jun 20;37:357-60. No abstract available.
PMID: 13875768 [PubMed - OLDMEDLINE for Pre1966]

447: MCALISTER R, MARTIN GM, BENDITT EP.
Evidence for multiple caeruloplasmin components in human serum.
Nature. 1961 Jun 3;190:927-9. No abstract available.
PMID: 13773716 [PubMed - OLDMEDLINE for Pre1966]

448: MCALISTER R, MARTIN GM, BENDITT EP.
Evidence for multiple caeruloplasmin components in human serum.
Nature. 1961 Jun 3;190:927-9. No abstract available.
PMID: 13773715 [PubMed - OLDMEDLINE for Pre1966]

449: MCALISTER R, MARTIN GM, BENDITT EP.
Evidence for multiple caeruloplasmin components in human serum.
Nature. 1961 Jun 3;190:927-9. No abstract available.
PMID: 13773714 [PubMed - OLDMEDLINE for Pre1966]

450: MCALISTER R, MARTIN GM, BENDITT EP.
Evidence for multiple caeruloplasmin components in human serum.
Nature. 1961 Jun 3;190:927-9. No abstract available.
PMID: 13773713 [PubMed - OLDMEDLINE for Pre1966]

451: MARTIN GM.
Current practices in general medicine. 20. Clinical applications of physical
medicine and rehabiliation to general medical problems.
Mayo Clin Proc. 1961 Feb 15;36:75-87. No abstract available.
PMID: 13767345 [PubMed - OLDMEDLINE for Pre1966]

452: MARTIN GM, SEIBEL L.
Preliminary report on the determination of blood urea nitrogen using individual
chromatography papers.
Can Med Assoc J. 1960 Dec 3;83:1214-5. No abstract available.
PMID: 13767344 [PubMed - OLDMEDLINE for Pre1966]

453: MARTIN GM, BENDITT EP, ERIKSEN N.
Enzymic oxidation of the indole nucleus of 5-hydroxytryptamine: properties of
an enzyme in human serum and of the products of oxidation.
Arch Biochem Biophys. 1960 Oct;90:208-17. No abstract available.
PMID: 13767343 [PubMed - OLDMEDLINE for Pre1966]

454: MARTIN GM, BENDITT EP, ERIKSEN N.
Vanadium catalysis of the oxidation of catechol amines, dihydroxyphenylalanine
and 5-hydroxyindoles.
Nature. 1960 Jun 11;186:884-5. No abstract available.
PMID: 14421674 [PubMed - OLDMEDLINE for Pre1966]

455: ERIKSEN N, MARTIN GM, BENDITT EP.
Oxidation of the indole nucleus of 5-hydroxytryptamine and the formation of
pigments: isolation and partial characterization of a dimer of
5-hydroxytryptamine.
J Biol Chem. 1960 Jun;235:1662-7. No abstract available.
PMID: 13820614 [PubMed - OLDMEDLINE for Pre1966]

456: MARTIN GM.
Sprains, strains, and whiplash injuries.
Phys Ther Rev. 1959 Dec;39:808-13. No abstract available.
PMID: 14421675 [PubMed - OLDMEDLINE for Pre1966]

457: MARTIN GM.
Physical therapy in the general practitioner's office.
Minn Med. 1959 Mar;42(3):235-9. No abstract available.
PMID: 13643953 [PubMed - OLDMEDLINE for Pre1966]

458: MARTIN GM.
A bipolar stimulating electrode.
Mayo Clin Proc. 1958 Jul 9;33(14):364-6. No abstract available.
PMID: 13601940 [PubMed - OLDMEDLINE for Pre1966]

459: DAVEY PW, MARTIN GM.
Malignant fibrous mesothelioma of peritoneum.
Can Med Assoc J. 1957 Oct 15;77(8):792-4. No abstract available.
PMID: 13472557 [PubMed - OLDMEDLINE for Pre1966]

460: MURRAY DJ, DAVEY PW, MARTIN GM.
Spontaneous rupture of the spleen in an erythroblastotic infant.
Can Med Assoc J. 1957 Jul 1;77(1):37-9. No abstract available.
PMID: 13437267 [PubMed - OLDMEDLINE for Pre1966]

461: DAVEY PW, MARTIN GM, HYNDMAN CF.
So-called eosinophilic granuloma of bone.
Can Med Assoc J. 1957 Apr 15;76(8):623-7. No abstract available.
PMID: 13426894 [PubMed - OLDMEDLINE for Pre1966]

462: MARTIN GM, STILLWELL GK.
Physical medicine and rehabilitation.
Med Prog. 1957;:260-78. No abstract available.
PMID: 13440291 [PubMed - OLDMEDLINE for Pre1966]

463: MARTIN GM.
Physical therapeutic methods in anorectal disease.
Am J Surg. 1956 Nov;92(5):792-8. No abstract available.
PMID: 13372887 [PubMed - OLDMEDLINE for Pre1966]

464: MARTIN GM.
Educational goals in physical medicine and rehabilitation.
Arch Phys Med Rehabil. 1956 Oct;37(10):597-603. No abstract available.
PMID: 13363574 [PubMed - OLDMEDLINE for Pre1966]

465: VERHAALEN RJ, KIRK WR, MARTIN GM, MYERS LN, EVANS J Jr.
A mental health seminar for general hospital personnel; a report.
Ment Hyg. 1956 Jul;40(3):413-26. No abstract available.
PMID: 13348086 [PubMed - OLDMEDLINE for Pre1966]

466: PEET RM, HENRIKSEN JD, ANDERSON TP, MARTIN GM.
Thoracic-outlet syndrome: evaluation of a therapeutic exercise program.
Mayo Clin Proc. 1956 May 2;31(9):281-7. No abstract available.
PMID: 13323047 [PubMed - OLDMEDLINE for Pre1966]

467: MARTIN GM, HERRICK JF.
Further evaluation of heating by microwaves and by infrared as used clinically.
J Am Med Assoc. 1955 Nov 26;159(13):1286-7. No abstract available.
PMID: 13271065 [PubMed - OLDMEDLINE for Pre1966]

468: LOWMAN EW, SOLOMON WM, HILL DF, MARTIN GM.
Panel on rehabilitation in rheumatoid arthritis.
GP. 1955 Nov;12(5):69-85. No abstract available.
PMID: 13262271 [PubMed - OLDMEDLINE for Pre1966]

469: MARTIN GM, MORE RH.
Pulmonary hyaline disease of infants.
Can Med Assoc J. 1955 Aug 15;73(4):273-7. No abstract available.
PMID: 13240599 [PubMed - OLDMEDLINE for Pre1966]

470: LEHMANN JF, ERICKSON DJ, MARTIN GM, KRUSEN FH.
Present value of ultrasonic diathermy.
J Am Med Assoc. 1955 Mar 19;157(12):996-9. No abstract available.
PMID: 14353635 [PubMed - OLDMEDLINE for Pre1966]

471: WAKIM KG, MARTIN GM, KRUSEN FH.
Influence of centripetal rhytymic compression on localized edema of an
extremity.
Arch Phys Med Rehabil. 1955 Feb;36(2):98-103. No abstract available.
PMID: 13229490 [PubMed - OLDMEDLINE for Pre1966]

472: ERIKSON DJ, KRUSEN FH, LEHMANN JF, MARTIN GM.
[Ultrasonic waves and microwave diathermy in the treatment of periarthritis of
the shoulder.]
Med Fis Rehabil. 1955;17(57-58):35-7. Spanish. No abstract available.
PMID: 13368939 [PubMed - OLDMEDLINE for Pre1966]

473: LEHMANN JF, ERICKSON DJ, MARTIN GM, KRUSEN FH.
Comparison of ultrasonic and microwave diathermy in the physical treatment of
periarthritis of the shoulder; study of the effects of ultrasonic and microwave
diathermy when employed in conjunction with massage and exercise.
Arch Phys Med Rehabil. 1954 Oct;35(10):627-34. No abstract available.
PMID: 13198433 [PubMed - OLDMEDLINE for Pre1966]

474: MARTIN GM, CORBIN KB.
An evaluation of conservative treatment for patients with cervical disk
syndrome.
Mayo Clin Proc. 1954 Jun 2;29(11):324-6. No abstract available.
PMID: 13177698 [PubMed - OLDMEDLINE for Pre1966]

475: MARTIN GM, CORBIN KB.
An evaluation of conservative treatment for patients with cervical disk
syndrome.
Arch Phys Med Rehabil. 1954 Feb;35(2):87-92. No abstract available.
PMID: 13125756 [PubMed - OLDMEDLINE for Pre1966]

476: GARFINKEL BT, MARTIN GM, WATT J, PAYNE FJ, MASON RP, HARDY AV.
Antibiotics in acute bacillary dysentery; observations in 1,408 cases with
positive cultures.
J Am Med Assoc. 1952 Apr 4;151(14):1157-60. No abstract available.
PMID: 13034449 [PubMed - OLDMEDLINE for Pre1966]

477: MARTIN GM, POLLEY HF, ANDERSON TP.
Physical medicine plus cortisone for rheumatoid arthritis.
J Am Med Assoc. 1952 Feb 16;148(7):525-8. No abstract available.
PMID: 14888518 [PubMed - OLDMEDLINE for Pre1966]

478: RAE JW Jr, MARTIN GM, TREANOR WJ, KRUSEN FH.
Clinical experiences with microwave diathermy.
Mayo Clin Proc. 1950 Jul 19;25(15):441-6. No abstract available.
PMID: 15430467 [PubMed - OLDMEDLINE for Pre1966]

479: MARTIN GM.
What every physician should know about prescribing physical therapy.
J Am Med Assoc. 1950 Feb 18;142(7):474-6. No abstract available.
PMID: 15409441 [PubMed - OLDMEDLINE for Pre1966]

480: MARTIN GM, ERICKSON DJ.
Medical diathermy.
J Am Med Assoc. 1950 Jan 7;142(1):27-32, illust. No abstract available.
PMID: 15395566 [PubMed - OLDMEDLINE for Pre1966]


signaling.
Genes Dev. 2006 Jan 15;20(2):174-84.
PMID: 16418483 [PubMed - indexed for MEDLINE]

Chris Hibbert said...

Well, it's not as if there's only one group talking, and all I have to do is examine their credentials to determine if they're smart enough that I should believe them. There are two groups, and they've both got credentials.

One is making an argument that a new approach to a problem is worth investigating. That side seems to have thought harder about how to solve the problem than the other side, which seems to be focused on basic research, and how things work in the body in the normal case. The second group has told the first group that it is ignoring the basic science, and the first group points to basic science that it thinks is in its favor. The second group made a lot of noise, and a respectable magazine challenged the critics to explain why the first group was wrong.

The submissions were judged not worthy. I wanted to know whether they had managed to undercut any of the basic arguments, since the judges didn't say what they believed and what they didn't. So I read the submissions.

I'm an educated lay person reading outside my field. So I can do a better job of evaluating what kinds of attacks were made than I can of deciding whose claims about the basic research are more correct. I wrote up what I learned by reading the articles. There may be real scientists who are convinced that SENS has absolutely no chance of working, but their best effort wasn't convincing to the judges or to me. And science isn't a matter of voting anyway.

I think de Grey is glad that the discussion has started. But the ball is back in the critic's court. I don't know whether the prize is still on offer if they can improve their argument, but they can still write papers explaining why it's not possible to clean up de Grey's 7 categories of damage or why doing so wouldn't help us to live longer. But I don't see how they can claim at this point that they've shown that SENS is worthless.

Anonymous said...

You say both sides have credentials. What are Aubrey de Grey's credentials, besides saying crazy things to get attention? Were you aware that what he calls his "Ph.D." from Cambridge isn't a real doctorate degree? What exactly is his training in biology or science? Who's lab did he do his work in?

I would think that an "educated lay person" who is thinking critically would be a bit more skeptical when someone (especially someone who looks like he escaped from the loony bin) claims people can live forever.

What I don't get is why these scientists even bother with de Grey.

Chris Hibbert said...

See http://www.sens.org/AdGbio.htm http://www.sens.org/AdG-CV.doc, and http://www.sens.org/AdGpubs.htm. He has a BA, MA, and PhD. I think the undergrad degree was in computer science, but he makes no secret of the fact that his background is engineering. He also makes no secret of the fact that he received his PhD by studying the subject on his own and convincing the faculty that he was qualified. He doesn't claim to have a laboratory background.

His list of refereed papers, and invited talks to scientific conferences is impressive.

People listen because other people who have heard him speak or read his work have recommended him. I was signed up for cryonics before I heard him talk, partly because I already found it plausible that the kind of work de Grey proposes will succeed.

Dr. Leonid Gavrilov, Ph.D. said...

Thank you for your interesting post!
I thought perhaps you may also find this related story interesting to you:
Longevity Science: SENS
http://longevity-science.blogspot.com/2007/01/sens.html

Longevity Science said...

Also perhaps you may be curious to see this new info on related topic:
New Books Discussing Aubrey de Grey Ideas
http://science-library.blogspot.com/2007/06/new-books-discussing-aubrey-de-grey.html
Shorter link:
http://tinyurl.com/29dt5o